BACKGROUND: C reactive protein (CRP) and serum amyloid A (SAA) are similarly sensitive indicators of inflammation, but discrepancies are recognized in several disease conditions. SAA levels are generally higher and vary more among individuals. The significance of the SAA/CRP ratio was evaluated in the estimation of SAA. METHODS: Sera of out-patients with rheumatoid arthritis (RA) and healthy subjects were measured for CRP and SAA cross-sectionally and longitudinally by a highly sensitive latex agglutination turbidimetric immunoassay. The results were classified into four groups according to the CRP concentration, and the SAA/CRP ratios were calculated and evaluated. RESULTS: In the cross-sectional study, CRP and SAA were shown to correlate significantly in sera of patients with RA, but not in healthy subjects. The SAA/CRP ratios were wide RA patients and tended to decrease in the range and mean values were observed depending on the concentration of CRP. In the longitudinal study, variations of the ratio among individuals were wide, but smaller and similar within individuals. The difference in magnitude of the ratios is due to the difference in SAA concentration. CONCLUSION: Variations of SAA/CRP ratios were affected by SAA concentrations. The ratio should be checked in the evaluation of SAA.
BACKGROUND:C reactive protein (CRP) and serum amyloid A (SAA) are similarly sensitive indicators of inflammation, but discrepancies are recognized in several disease conditions. SAA levels are generally higher and vary more among individuals. The significance of the SAA/CRP ratio was evaluated in the estimation of SAA. METHODS: Sera of out-patients with rheumatoid arthritis (RA) and healthy subjects were measured for CRP and SAA cross-sectionally and longitudinally by a highly sensitive latex agglutination turbidimetric immunoassay. The results were classified into four groups according to the CRP concentration, and the SAA/CRP ratios were calculated and evaluated. RESULTS: In the cross-sectional study, CRP and SAA were shown to correlate significantly in sera of patients with RA, but not in healthy subjects. The SAA/CRP ratios were wide RApatients and tended to decrease in the range and mean values were observed depending on the concentration of CRP. In the longitudinal study, variations of the ratio among individuals were wide, but smaller and similar within individuals. The difference in magnitude of the ratios is due to the difference in SAA concentration. CONCLUSION: Variations of SAA/CRP ratios were affected by SAA concentrations. The ratio should be checked in the evaluation of SAA.
Authors: Dijana Vitko; Patricia S Cho; Stephen A Kostel; Shannon E DiMartino; Lily D Cabour; Matthew A Migliozzi; Tanya Logvinenko; Peter G Warren; John W Froehlich; Richard S Lee Journal: Mol Cell Proteomics Date: 2020-01-02 Impact factor: 5.911
Authors: Ali A Ghweil; Heba A Osman; Mohammed H Hassan; Abeer Mm Sabry; Reem E Mahdy; Ahmed Rh Ahmed; Ahmed Okasha; Ashraf Khodeary; Hesham H Ameen Journal: Cancer Manag Res Date: 2020-01-08 Impact factor: 3.989
Authors: Mahmood M T M Ally; Bridget Hodkinson; Pieter W A Meyer; Eustasius Musenge; Mohammed Tikly; Ronald Anderson Journal: Mediators Inflamm Date: 2013-04-07 Impact factor: 4.711
Authors: J L Kuiper; J S W Lind; H J M Groen; J Roder; J Grigorieva; H Roder; A M C Dingemans; E F Smit Journal: Br J Cancer Date: 2012-10-18 Impact factor: 7.640
Authors: Christoph Stettler; Nicholas Witt; Robyn J Tapp; Simon Thom; Sabin Allemann; Therese Tillin; Alice Stanton; Eoin O'Brien; Neil Poulter; J Ruth Gallimore; Alun D Hughes; Nish Chaturvedi Journal: Diabetes Care Date: 2009-02-24 Impact factor: 19.112
Authors: Alfonso Martínez; Jose Luis Santiago; Jezabel Varadé; Ana Márquez; José Ramón Lamas; Juan Luis Mendoza; Hermenegildo de la Calle; Manuel Díaz-Rubio; Emilio G de la Concha; Benjamín Fernández-Gutiérrez; Elena Urcelay Journal: BMC Genomics Date: 2008-07-14 Impact factor: 3.969