Multiple fixed drug eruption due to drug combination.

We report the case of a multiple fixed drug eruption (FDE) after taking 1 g of PL and 100 mg of levofloxacin (Cravit) at the same time. Patch tests with PL alone, levofloxacin alone and the combination of PL and levofloxacin were all negative on the involved and uninvolved sites. Lymphocytic stimulation tests were also negative for PL alone, levofloxacin alone and the combination of PL and levofloxacin. Oral provocation tests with PL alone or levofloxacin alone produced no reactivation. However, we could provoke multiple erythematous plaques on the involved areas by taking a 1/10th dose of the combination of PL and levofloxacin at the same time. Drug eruption due to a drug combination appears to be very rare. This is the first case of multiple FDE caused by taking PL-levofloxacin combination.