OBJECTIVE: To investigate the relationship of p53 protein expression and primary tumour volume in patients with nasopharyngeal carcinoma. DESIGN: Retrospective study. SETTING: Tertiary care centre. METHOD: Forty-two newly diagnosed patients participated in the study. MAIN OUTCOME MEASURES: The relationship between p53 status, TNM stage, and computed tomography-derived primary tumour volume. RESULTS: In patients with high p53 stains, the tumour volume was larger (p = .03). p53 was found to be independent of clinical stage (p = .84). CONCLUSION: There is a positive correlation between primary tumour volume and p53 status.
OBJECTIVE: To investigate the relationship of p53 protein expression and primary tumour volume in patients with nasopharyngeal carcinoma. DESIGN: Retrospective study. SETTING: Tertiary care centre. METHOD: Forty-two newly diagnosed patients participated in the study. MAIN OUTCOME MEASURES: The relationship between p53 status, TNM stage, and computed tomography-derived primary tumour volume. RESULTS: In patients with high p53 stains, the tumour volume was larger (p = .03). p53 was found to be independent of clinical stage (p = .84). CONCLUSION: There is a positive correlation between primary tumour volume and p53 status.