| Literature DB >> 15930259 |
Masao Matsuoka1, Kuan-Teh Jeang.
Abstract
It has been 25 years since the discovery of human T-cell leukemia virus type I (HTLV-I) and its role in adult T-cell leukemia. Here, in brief, we review the current state of our understanding of HTLV-I epidemiology, viral biology, pathogenesis, and treatment. We discuss how HTLV-I may transform cells through destabilization of cellular genomic integrity and induction of cellular tolerance for chromosomal errors.Entities:
Mesh:
Year: 2005 PMID: 15930259 DOI: 10.1158/0008-5472.CAN-05-0559
Source DB: PubMed Journal: Cancer Res ISSN: 0008-5472 Impact factor: 12.701