OBJECTIVE: This study investigated changes in the cognitive architecture of N-back performance in schizophrenia. METHOD: N-back performance of 12 patients with first-episode, drug-naive schizophrenia and matched healthy comparison subjects was studied in a reaction-time decomposition paradigm. RESULTS: Imposition of a working memory load led to a significant drop in response accuracy in patients. Reaction-time decomposition suggested slowing of visuomotor and choice reaction processing as well as an inability of parallel processing directed by working memory. DISCUSSION: Although N-back tasks validly access working memory function as a neurocognitive trait in the illness, several additional subprocesses and the ability for cognitive parallel processing are altered and require further study in schizophrenia.
OBJECTIVE: This study investigated changes in the cognitive architecture of N-back performance in schizophrenia. METHOD:N-back performance of 12 patients with first-episode, drug-naive schizophrenia and matched healthy comparison subjects was studied in a reaction-time decomposition paradigm. RESULTS: Imposition of a working memory load led to a significant drop in response accuracy in patients. Reaction-time decomposition suggested slowing of visuomotor and choice reaction processing as well as an inability of parallel processing directed by working memory. DISCUSSION: Although N-back tasks validly access working memory function as a neurocognitive trait in the illness, several additional subprocesses and the ability for cognitive parallel processing are altered and require further study in schizophrenia.
Authors: Urs Braun; Axel Schäfer; Henrik Walter; Susanne Erk; Nina Romanczuk-Seiferth; Leila Haddad; Janina I Schweiger; Oliver Grimm; Andreas Heinz; Heike Tost; Andreas Meyer-Lindenberg; Danielle S Bassett Journal: Proc Natl Acad Sci U S A Date: 2015-08-31 Impact factor: 11.205
Authors: Linda Chang; Joseph Friedman; Thomas Ernst; Kai Zhong; Nicholas D Tsopelas; Kenneth Davis Journal: Biol Psychiatry Date: 2007-08-13 Impact factor: 13.382
Authors: Johanna Seitz; Jessica X Zuo; Amanda E Lyall; Nikos Makris; Zora Kikinis; Sylvain Bouix; Ofer Pasternak; Eli Fredman; Jonathan Duskin; Jill M Goldstein; Tracey L Petryshen; Raquelle I Mesholam-Gately; Joanne Wojcik; Robert W McCarley; Larry J Seidman; Martha E Shenton; Inga K Koerte; Marek Kubicki Journal: Schizophr Bull Date: 2016-03-23 Impact factor: 9.306