Literature DB >> 15927480

Black cohosh: just another phytoestrogen?

Volker Viereck1, Günter Emons, Wolfgang Wuttke.   

Abstract

Most clinical trials on phytoestrogens detected no significant effects on classic menopausal symptoms. Soy-rich diets positively influence certain aspects (e.g. sleep disturbances and mood swings), but the level of relief is low. Duration of the specific diet before menopause onset predicts the extent of the benefit. Isoflavones exert competitive effects at the estrogen receptor and might interfere with anti-proliferative properties of endocrine anti-cancer therapies. Clinical trials on effects of Actaea racemosa (black cohosh) extracts on menopausal symptoms have yielded more positive results. Two recent studies showed excellent efficacy against classic menopausal complaints and osteoprotective properties, and extracts were deemed safe even when the dosage was increased threefold. Furthermore, several studies suggest that A. racemosa extracts might help control psychic problems typically found during menopausal transition.

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Year:  2005        PMID: 15927480     DOI: 10.1016/j.tem.2005.05.002

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN: 1043-2760            Impact factor:   12.015


  14 in total

1.  Pregnane X receptor-mediated induction of Cyp3a by black cohosh.

Authors:  Xiaoyan Pang; Jie Cheng; Kristopher W Krausz; De-an Guo; Frank J Gonzalez
Journal:  Xenobiotica       Date:  2010-10-27       Impact factor: 1.908

2.  Feruloyl dopamine-O-hexosides are efficient marker compounds as orthogonal validation for authentication of black cohosh (Actaea racemosa)-an UHPLC-HRAM-MS chemometrics study.

Authors:  Ping Geng; James M Harnly; Jianghao Sun; Mengliang Zhang; Pei Chen
Journal:  Anal Bioanal Chem       Date:  2017-02-03       Impact factor: 4.142

3.  A Preliminary Study on the Effects of Black Cohosh Preparations on Bone Metabolism of Rat Models With GnRH-a-Induced Peri-Menopausal Symptoms.

Authors:  Zhenyue Qin; Zhiyong Dong; Junling Liu; Ahong Zhong; Mingyue Bao; Huihui Wang; Hongxia Yu; Shoufeng Zhang; Wendi Zhang; Li Shen; Jie Wu; Jiming Chen
Journal:  Front Endocrinol (Lausanne)       Date:  2022-06-09       Impact factor: 6.055

4.  Phytochemistry of cimicifugic acids and associated bases in Cimicifuga racemosa root extracts.

Authors:  Tanja Gödecke; Dejan Nikolic; David C Lankin; Shao-Nong Chen; Sharla L Powell; Birgit Dietz; Judy L Bolton; Richard B van Breemen; Norman R Farnsworth; Guido F Pauli
Journal:  Phytochem Anal       Date:  2009 Mar-Apr       Impact factor: 3.373

5.  Liver Injury with Features Mimicking Autoimmune Hepatitis following the Use of Black Cohosh.

Authors:  Grace Guzman; Eric R Kallwitz; Christina Wojewoda; Rohini Chennuri; Jamie Berkes; Thomas J Layden; Scott J Cotler
Journal:  Case Rep Med       Date:  2010-01-10

6.  Characterization of antiestrogenic activity of the Chinese herb, prunella vulgaris, using in vitro and in vivo (Mouse Xenograft) models.

Authors:  Nancy H Collins; Elizabeth C Lessey; Carolyn D DuSell; Donald P McDonnell; Lindsay Fowler; Wilder A Palomino; Maria J Illera; Xianzhong Yu; Bilan Mo; Angela M Houwing; Bruce A Lessey
Journal:  Biol Reprod       Date:  2008-10-15       Impact factor: 4.285

7.  Guanidine alkaloids and Pictet-Spengler adducts from black cohosh (Cimicifuga racemosa).

Authors:  Tanja Gödecke; David C Lankin; Dejan Nikolic; Shao-Nong Chen; Richard B van Breemen; Norman R Farnsworth; Guido F Pauli
Journal:  J Nat Prod       Date:  2009-03-27       Impact factor: 4.050

8.  Gene expression profiling reveals effects of Cimicifuga racemosa (L.) NUTT. (black cohosh) on the estrogen receptor positive human breast cancer cell line MCF-7.

Authors:  Friedemann Gaube; Stefan Wolfl; Larissa Pusch; Torsten C Kroll; Matthias Hamburger
Journal:  BMC Pharmacol       Date:  2007-09-20

Review 9.  Cytochrome P450 enzyme mediated herbal drug interactions (Part 2).

Authors:  Sompon Wanwimolruk; Kamonrat Phopin; Virapong Prachayasittikul
Journal:  EXCLI J       Date:  2014-08-20       Impact factor: 4.068

Review 10.  Phytoestrogens in postmenopause: the state of the art from a chemical, pharmacological and regulatory perspective.

Authors:  Elisabetta Poluzzi; Carlo Piccinni; Emanuel Raschi; Angela Rampa; Maurizio Recanatini; Fabrizio De Ponti
Journal:  Curr Med Chem       Date:  2014       Impact factor: 4.530

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