PURPOSE: Between December 1998 and October 2001, patients <19 years old were treated for standard-risk medulloblastoma according to the Medulloblastome-Société Française d'Oncologie Pédiatrique 1998 (M-SFOP 98) protocol. Patients received hyperfractionated radiotherapy (36 Gy in 36 fractions) to the craniospinal axis, a boost with conformal therapy restricted to the tumor bed (to a total dose of 68 Gy in 68 fractions), and no chemotherapy. Records of craniospinal irradiation were reviewed before treatment start. RESULTS: A total of 48 patients were considered assessable. With a median follow-up of 45.7 months, the overall survival and progression-free survival rate at 3 years was 89% and 81%, respectively. Fourteen major deviations were detected and eight were corrected. No relapses occurred in the frontal region and none occurred in the posterior fossa outside the boost volume. Nine patients were available for volume calculation without reduction of the volume irradiated. We observed a reduction in the subtentorial volume irradiated to >60 Gy, but a slight increase in the volume irradiated to 40 Gy. No decrease in intelligence was observed in the 22 children tested during the first 2 years. CONCLUSION: This hyperfractionated radiotherapy protocol with a reduced boost volume and without chemotherapy was not associated with early relapses in children. Moreover, intellectual function seemed to be preserved. These results are promising.
PURPOSE: Between December 1998 and October 2001, patients <19 years old were treated for standard-risk medulloblastoma according to the Medulloblastome-Société Française d'Oncologie Pédiatrique 1998 (M-SFOP 98) protocol. Patients received hyperfractionated radiotherapy (36 Gy in 36 fractions) to the craniospinal axis, a boost with conformal therapy restricted to the tumor bed (to a total dose of 68 Gy in 68 fractions), and no chemotherapy. Records of craniospinal irradiation were reviewed before treatment start. RESULTS: A total of 48 patients were considered assessable. With a median follow-up of 45.7 months, the overall survival and progression-free survival rate at 3 years was 89% and 81%, respectively. Fourteen major deviations were detected and eight were corrected. No relapses occurred in the frontal region and none occurred in the posterior fossa outside the boost volume. Nine patients were available for volume calculation without reduction of the volume irradiated. We observed a reduction in the subtentorial volume irradiated to >60 Gy, but a slight increase in the volume irradiated to 40 Gy. No decrease in intelligence was observed in the 22 children tested during the first 2 years. CONCLUSION: This hyperfractionated radiotherapy protocol with a reduced boost volume and without chemotherapy was not associated with early relapses in children. Moreover, intellectual function seemed to be preserved. These results are promising.
Authors: D Kombogiorgas; S Sgouros; A R Walsh; A D Hockley; M Stevens; R Grundy; A Peet; M English; D Spooner Journal: Childs Nerv Syst Date: 2006-11-22 Impact factor: 1.475
Authors: Thomas E Merchant; Larry E Kun; Matthew J Krasin; Dana Wallace; Murali M Chintagumpala; Shiao Y Woo; David M Ashley; Maree Sexton; Stewart J Kellie; Verity Ahern; Amar Gajjar Journal: Int J Radiat Oncol Biol Phys Date: 2007-09-24 Impact factor: 7.038
Authors: Stefan Dietzsch; Annett Braesigk; Clemens Seidel; Julia Remmele; Ralf Kitzing; Tina Schlender; Martin Mynarek; Dirk Geismar; Karolina Jablonska; Rudolf Schwarz; Montserrat Pazos; Marc Walser; Silke Frick; Kristin Gurtner; Christiane Matuschek; Semi Ben Harrabi; Albrecht Glück; Victor Lewitzki; Karin Dieckmann; Martin Benesch; Nicolas U Gerber; Stefan Rutkowski; Beate Timmermann; Rolf-Dieter Kortmann Journal: Strahlenther Onkol Date: 2020-11-23 Impact factor: 3.621