Literature DB >> 159268

Alkali-labile sites and post-irradiation effects in gamma-irradiated biologically active double-stranded DNA in aqueous solution.

M V Lafleur, J Woldhuis, H Loman.   

Abstract

Gamma-irradiation of double-stranded RF-DNA of bacteriophage phi X174 in aqueous solution in the presence of oxygen produces at least one type of alkali-labile site. It is lethal and gives rise to breaks by alkali and is identical with the damage which becomes manifest by post-irradiation heat treatment. The effect of alkali is dependent on temperature. Furthermore, the excision repair system is not involved in eliminating lethal nucleotide damage in RFI-DNA.

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Year:  1979        PMID： 159268     DOI： 10.1080/09553007914551011

Source DB:  PubMed          Journal:  Int J Radiat Biol Relat Stud Phys Chem Med        ISSN： 0020-7616


  6 in total

1.  Correlation of free radical yields with strand break yields produced in plasmid DNA by the direct effect of ionizing radiation.

Authors:  Shubhadeep Purkayastha; Jamie R Milligan; William A Bernhard
Journal:  J Phys Chem B       Date:  2005-09-08       Impact factor: 2.991

2.  Characterization of radiation damage to DNA by reaction with borohydride.

Authors:  K A Schellenberg; J Shaeffer; R K Nichols; D Gates
Journal:  Nucleic Acids Res       Date:  1981-08-11       Impact factor: 16.971

3.  Reduced contribution of thermally labile sugar lesions to DNA double strand break formation after exposure to heavy ions.

Authors:  Satyendra K Singh; Alena Bencsik-Theilen; Emil Mladenov; Burkhard Jakob; Gisela Taucher-Scholz; George Iliakis
Journal:  Radiat Oncol       Date:  2013-04-02       Impact factor: 3.481

4.  Post-irradiation chemical processing of DNA damage generates double-strand breaks in cells already engaged in repair.

Authors:  Satyendra K Singh; Minli Wang; Christian Staudt; George Iliakis
Journal:  Nucleic Acids Res       Date:  2011-07-10       Impact factor: 16.971

Review 5.  DNA double-strand-break complexity levels and their possible contributions to the probability for error-prone processing and repair pathway choice.

Authors:  Agnes Schipler; George Iliakis
Journal:  Nucleic Acids Res       Date:  2013-06-26       Impact factor: 16.971

Review 6.  DNA Damage Clustering after Ionizing Radiation and Consequences in the Processing of Chromatin Breaks.

Authors:  Veronika Mladenova; Emil Mladenov; Martin Stuschke; George Iliakis
Journal:  Molecules       Date:  2022-02-24       Impact factor: 4.411
  6 in total

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