Literature DB >> 15926797

Nonactin biosynthesis: the product of the resistance gene degrades nonactin stereospecifically to form homochiral nonactate dimers.

James E Cox1, Nigel D Priestley.   

Abstract

Heterologous expression of the tetranactin resistance gene nonR in E. coli gave a his6-tagged protein that catalyzed the stereoselective hydrolysis of the chiral macrotetrolide antibiotic nonactin into equivalent, chiral, inactive nonactate dimer species. No trimeric nonactate was produced in the reaction.

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Year:  2005        PMID： 15926797     DOI： 10.1021/ja050068k

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  4 in total

Review 1.  Enantiomeric natural products: occurrence and biogenesis.

Authors:  Jennifer M Finefield; David H Sherman; Martin Kreitman; Robert M Williams
Journal:  Angew Chem Int Ed Engl       Date:  2012-05-03       Impact factor: 15.336

2.  Natural product derivatives with bactericidal activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis.

Authors:  Joshua B Phillips; Adrienne E Smith; Brian R Kusche; Bradley A Bessette; P Whitney Swain; Stephen C Bergmeier; Mark C McMills; Dennis L Wright; Nigel D Priestley
Journal:  Bioorg Med Chem Lett       Date:  2010-07-07       Impact factor: 2.823

3.  Alternating pattern of stereochemistry in the nonactin macrocycle is required for antibacterial activity and efficient ion binding.

Authors:  Brian R Kusche; Adrienne E Smith; Michele A McGuirl; Nigel D Priestley
Journal:  J Am Chem Soc       Date:  2009-12-02       Impact factor: 15.419

4.  Nonactin biosynthesis: setting limits on what can be achieved with precursor-directed biosynthesis.

Authors:  Brian R Kusche; Joshua B Phillips; Nigel D Priestley
Journal:  Bioorg Med Chem Lett       Date:  2008-12-30       Impact factor: 2.823
  4 in total

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