Literature DB >> 15925409

Internalization and mechanism of action of clostridial toxins in neurons.

Carlotta Grumelli1, Claudia Verderio, Davide Pozzi, Ornella Rossetto, Cesare Montecucco, Michela Matteoli.   

Abstract

Botulinum toxins are metalloproteases that act inside nerve terminals and block neurotransmitter release via their activity directed specifically on SNARE proteins. This review summarizes data on botulinum toxin modes of binding, sites of action, and biochemical activities. Their use in cell biology and neuroscience is considered, as well as their therapeutic utilization in human diseases characterized by hyperfunction of cholinergic terminals.

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Year:  2005        PMID： 15925409     DOI： 10.1016/j.neuro.2004.12.012

Source DB:  PubMed          Journal:  Neurotoxicology        ISSN： 0161-813X            Impact factor:   4.294


  18 in total

1.  Botulinum neurotoxin light chain refolds at endosomal pH for its translocation.

Authors:  Shuowei Cai; Roshan Kukreja; Sue Shoesmith; Tzuu-Wang Chang; Bal Ram Singh
Journal:  Protein J       Date:  2006-12       Impact factor: 2.371

2.  Activation of the tonic GABAC receptor current in retinal bipolar cell terminals by nonvesicular GABA release.

Authors:  S M Jones; M J Palmer
Journal:  J Neurophysiol       Date:  2009-06-03       Impact factor: 2.714

Review 3.  The Molecular Basis of Toxins' Interactions with Intracellular Signaling via Discrete Portals.

Authors:  Adi Lahiani; Ephraim Yavin; Philip Lazarovici
Journal:  Toxins (Basel)       Date:  2017-03-16       Impact factor: 4.546

Review 4.  Recent developments in cell-based assays and stem cell technologies for botulinum neurotoxin research and drug discovery.

Authors:  Erkan Kiris; Krishna P Kota; James C Burnett; Veronica Soloveva; Christopher D Kane; Sina Bavari
Journal:  Expert Rev Mol Diagn       Date:  2014-01-23       Impact factor: 5.225

5.  Embryonic stem cell-derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discovery.

Authors:  Erkan Kiris; Jonathan E Nuss; James C Burnett; Krishna P Kota; Dawn C Koh; Laura M Wanner; Edna Torres-Melendez; Rick Gussio; Lino Tessarollo; Sina Bavari
Journal:  Stem Cell Res       Date:  2011-01-19       Impact factor: 2.020

6.  Long-term follow-up of botulinum toxin therapy for focal hand dystonia: outcome at 10 years or more.

Authors:  Codrin Lungu; Barbara I Karp; Katharine Alter; Regina Zolbrod; Mark Hallett
Journal:  Mov Disord       Date:  2011-02-01       Impact factor: 10.338

7.  AMPA and metabotropic excitoxicity explain subplate neuron vulnerability.

Authors:  Vien Nguyen; Patrick S McQuillen
Journal:  Neurobiol Dis       Date:  2009-10-12       Impact factor: 5.996

8.  Time-course transcriptomics reveals that amino acids catabolism plays a key role in toxinogenesis and morphology in Clostridium tetani.

Authors:  Camila A Orellana; Nicolas E Zaragoza; Cuauhtemoc Licona-Cassani; Robin W Palfreyman; Nicholas Cowie; Glenn Moonen; George Moutafis; John Power; Lars K Nielsen; Esteban Marcellin
Journal:  J Ind Microbiol Biotechnol       Date:  2020-11-11       Impact factor: 3.346

9.  Recombinant derivatives of botulinum neurotoxin A engineered for trafficking studies and neuronal delivery.

Authors:  Philip A Band; Steven Blais; Thomas A Neubert; Timothy J Cardozo; Konstantin Ichtchenko
Journal:  Protein Expr Purif       Date:  2010-01-04       Impact factor: 1.650

10.  Cellular Protection of SNAP-25 against Botulinum Neurotoxin/A: Inhibition of Thioredoxin Reductase through a Suicide Substrate Mechanism.

Authors:  Hajime Seki; Song Xue; Sabine Pellett; Peter Šilhár; Eric A Johnson; Kim D Janda
Journal:  J Am Chem Soc       Date:  2016-04-20       Impact factor: 15.419
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