Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Synthesis of substituted indole derivatives as a new class of antimalarial agents.

Literature DB >> 15925306

Synthesis of substituted indole derivatives as a new class of antimalarial agents.

Anu Agarwal¹, Kumkum Srivastava, S K Puri, Prem M S Chauhan.

Abstract

A series of substituted indole derivatives were synthesized and evaluated for their in vitro antimalarial activity against P. falciparum. Out of the 24 compounds synthesized six compounds have shown MIC of 1 microg/mL. These compounds are in vitro several folds more active than pyrimethamine.

Entities: Chemical Species

Mesh：

Substances：

Year: 2005 PMID： 15925306 DOI： 10.1016/j.bmcl.2005.04.011

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

Keyword Cloud
Cited

7 in total

1. Synthesis of novel star-shaped molecules based on a 1,3,5-triazine core linked to different heterocyclic systems as novel hybrid molecules.

Authors: Hadeer M Diab; Mostafa E Salem; Ismail A Abdelhamid; Ahmed H M Elwahy
Journal: RSC Adv Date: 2020-12-14 Impact factor: 4.036

2. Decoding the Role of Melatonin Structure on Plasmodium falciparum Human Malaria Parasites Synchronization Using 2-Sulfenylindoles Derivatives.

Authors: Lenna Rosanie Cordero Mallaupoma; Bárbara Karina de Menezes Dias; Maneesh Kumar Singh; Rute Isabel Honorio; Myna Nakabashi; Camila de Menezes Kisukuri; Márcio Weber Paixão; Celia R S Garcia
Journal: Biomolecules Date: 2022-04-26

3. Transition-metal-free synthesis of pyrimidines from lignin β-O-4 segments via a one-pot multi-component reaction.

Authors: Bo Zhang; Tenglong Guo; Zhewei Li; Fritz E Kühn; Ming Lei; Zongbao K Zhao; Jianliang Xiao; Jian Zhang; Dezhu Xu; Tao Zhang; Changzhi Li
Journal: Nat Commun Date: 2022-06-11 Impact factor: 17.694

4. Synthesis, biological evaluation and molecular docking studies of trans-indole-3-acrylamide derivatives, a new class of tubulin polymerization inhibitors.

Authors: Sultan Nacak Baytas; Nazan Inceler; Akin Yilmaz; Abdurrahman Olgac; Sevda Menevse; Erden Banoglu; Ernest Hamel; Roberta Bortolozzi; Giampietro Viola
Journal: Bioorg Med Chem Date: 2014-04-20 Impact factor: 3.641

Synthesis of substituted indole derivatives as a new class of antimalarial agents.

1. Synthesis of novel star-shaped molecules based on a 1,3,5-triazine core linked to different heterocyclic systems as novel hybrid molecules.

2. Decoding the Role of Melatonin Structure on Plasmodium falciparum Human Malaria Parasites Synchronization Using 2-Sulfenylindoles Derivatives.

3. Transition-metal-free synthesis of pyrimidines from lignin β-O-4 segments via a one-pot multi-component reaction.

4. Synthesis, biological evaluation and molecular docking studies of trans-indole-3-acrylamide derivatives, a new class of tubulin polymerization inhibitors.

5. Synthesis of diindolylmethane (DIM) bearing thiadiazole derivatives as a potent urease inhibitor.

6. Design and Synthesis of Benzimidazole-Chalcone Derivatives as Potential Anticancer Agents.

Review 7. Role of Melatonin in the Synchronization of Asexual Forms in the Parasite Plasmodium falciparum.