OBJECTIVE: To compare the effect of HMG and rhFSH on oocyte quality in ICSI cycle. SETTING: Vali-e-Asr university teaching hospital. METHOD: Prospective single-blind randomized clinical trial. SUBJECTS:Sixty women undergoing ovarian stimulation for ICSI were randomized to receive a standard protocol of either HMG or rhFSH in down-regulation cycles. INTERVENTIONS: Prior to microinjection, each oocyte was assessed regarding the nuclear maturity, morphology of zona plucida, cytoplasmic appearance and polar body morphology. Fertilization rate was followed. MAIN OUTCOME: The percentage of metaphase II oocytes in HMG andrhFSH groups. STATISTICAL ANALYSIS: Statistical analyses were carried out by the Mann-Whitney, Fisher's exact, chi2 tests and Student's t-test. RESULTS: No significant differences were found between two groups in regard to the demographic data, the ovarian response and pregnancy/implantation rates (P>0.05). The percentage of metaphase II oocytes in HMG andrhFSH groups were 81.3% versus 80.6%, respectively. CONCLUSIONS: There were no significant differences between parameters such as, oocyte quality and percentage of metaphase II oocytes between these two groups.
RCT Entities:
OBJECTIVE: To compare the effect of HMG and rhFSH on oocyte quality in ICSI cycle. SETTING: Vali-e-Asr university teaching hospital. METHOD: Prospective single-blind randomized clinical trial. SUBJECTS: Sixty women undergoing ovarian stimulation for ICSI were randomized to receive a standard protocol of either HMG or rhFSH in down-regulation cycles. INTERVENTIONS: Prior to microinjection, each oocyte was assessed regarding the nuclear maturity, morphology of zona plucida, cytoplasmic appearance and polar body morphology. Fertilization rate was followed. MAIN OUTCOME: The percentage of metaphase II oocytes in HMG and rhFSH groups. STATISTICAL ANALYSIS: Statistical analyses were carried out by the Mann-Whitney, Fisher's exact, chi2 tests and Student's t-test. RESULTS: No significant differences were found between two groups in regard to the demographic data, the ovarian response and pregnancy/implantation rates (P>0.05). The percentage of metaphase II oocytes in HMG and rhFSH groups were 81.3% versus 80.6%, respectively. CONCLUSIONS: There were no significant differences between parameters such as, oocyte quality and percentage of metaphase II oocytes between these two groups.
Authors: Ana Marcia M Cota; Joao Batista A Oliveira; Claudia G Petersen; Ana L Mauri; Fabiana C Massaro; Liliane F I Silva; Andreia Nicoletti; Mario Cavagna; Ricardo L R Baruffi; José G Franco Journal: Reprod Biol Endocrinol Date: 2012-04-27 Impact factor: 5.211
Authors: P E Levi Setti; C Alviggi; G L Colombo; C Pisanelli; C Ripellino; S Longobardi; P L Canonico; G De Placido Journal: J Endocrinol Invest Date: 2014-12-06 Impact factor: 4.256