Literature DB >> 15924984

Reversal of life-threatening, drug-related potassium-channel syndrome by glibenclamide.

Mervyn Singer1, Flaminia Coluzzi, Alastair O'Brien, Lucie H Clapp.   

Abstract

We describe three critically ill patients who received drugs with K(ATP) channel-opening properties and subsequently developed severe life-threatening complications, including hyperkalaemia and cardiovascular disturbances. Administration of the sulfonylurea-receptor inhibitor glibenclamide promptly reversed these abnormalities. Over the past 3 years, we have seen this syndrome and response in five patients taking nicorandil, ciclosporin, or isoflurane, which suggests that this disorder arises more frequently than is currently realised.

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Year:  2005        PMID： 15924984     DOI： 10.1016/S0140-6736(05)66619-6

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  12 in total

1.  Inotropes and vasopressors: more than haemodynamics!

Authors:  Hendrik Bracht; Enrico Calzia; Michael Georgieff; Joel Singer; Peter Radermacher; James A Russell
Journal:  Br J Pharmacol       Date:  2012-04       Impact factor: 8.739

2.  Vascular K ATP channels: dephosphorylation and deactivation.

Authors:  Paolo Tammaro
Journal:  Br J Pharmacol       Date:  2009-06       Impact factor: 8.739

3.  Early potassium channel blockade improves sepsis-induced organ damage and cardiovascular dysfunction.

Authors:  R Sordi; D Fernandes; B T Heckert; J Assreuy
Journal:  Br J Pharmacol       Date:  2011-07       Impact factor: 8.739

4.  Ca2+/calcineurin regulation of cloned vascular K ATP channels: crosstalk with the protein kinase A pathway.

Authors:  N N Orie; A M Thomas; B A Perrino; A Tinker; L H Clapp
Journal:  Br J Pharmacol       Date:  2009-05-07       Impact factor: 8.739

5.  Nicorandil a magic bullet or a double edged sword in critically ill COVID-19 patients?

Authors:  Tajamul H Mir; Parvaiz A Zargar; Bushra Jabeen; Aariba Zahoor
Journal:  Clin Exp Pharmacol Physiol       Date:  2021-03-08       Impact factor: 2.557

6.  Glibenclamide: A second wind for refractory hyperkalemia.

Authors:  Subramanian Senthilkumaran; Ritesh G Menezes; Srinivasan Jayaraman; Ponniah Thirumalaikolundusubramanian
Journal:  Indian J Crit Care Med       Date:  2014-11

7.  Refractory hyperkalemia related to heparin abuse.

Authors:  Himmatrao S Bawaskar; Parag H Bawaskar; Pramodini H Bawaskar
Journal:  Indian J Crit Care Med       Date:  2014-11

8.  Intractable hyperkalemia due to nicorandil induced potassium channel syndrome.

Authors:  Vivek Chowdhry; B B Mohanty
Journal:  Ann Card Anaesth       Date:  2015 Jan-Mar

9.  Hyperkalemia accompanies hemorrhagic shock and correlates with mortality.

Authors:  Joel Avancini Rocha Filho; Ricardo Souza Nani; Luiz Augusto Carneiro D'Albuquerque; Carla Augusto Holms; João Plínio Souza Rocha; Luís Marcelo Sá Malbouisson; Marcel Cerqueira César Machado; Maria José Carvalho Carmona; José Otávio Costa Auler Júnior
Journal:  Clinics (Sao Paulo)       Date:  2009       Impact factor: 2.365

10.  Nicorandil-induced hyperkalemia in a uremic patient.

Authors:  Hung-Hao Lee; Po-Chao Hsu; Tsung-Hsien Lin; Wen-Ter Lai; Sheng-Hsiung Sheu
Journal:  Case Rep Med       Date:  2012-10-18
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