| Literature DB >> 1592392 |
D Hirayama1, T Fujimori, K Satonaka, T Nakamura, S Kitazawa, M Horio, S Maeda, K Nagasako.
Abstract
We report that the penetrating type of early gastric cancer (PEN) is a specific type of early gastric cancer and that the poorly differentiated PEN type could be considered an initial lesion of linitis plastica-type cancer. We performed an immunohistochemical study to clarify the role of growth factors (epidermal growth factor [EGF] and transforming growth factor-beta [TGF-beta]) in the PEN type of early gastric cancer. The results indicated that the PEN type of early gastric cancer has a high growth capacity. Moreover, it was suggested that EGF was involved in its specific infiltrative growth and that both EGF and TGF-beta were involved in its specific scirrhous growth. From these findings, it was assumed that the immunohistochemical staining of EGF and TGF-beta in endoscopic biopsy specimens was useful for the diagnosis of the PEN type of gastric cancer and also for the diagnosis of the initial lesion of linitis plastica-type gastric cancer.Entities:
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Year: 1992 PMID： 1592392 DOI： 10.1016/0046-8177(92)90325-w
Source DB: PubMed Journal: Hum Pathol ISSN： 0046-8177 Impact factor: 3.466