Literature DB >> 15923038

Intrinsic mechanisms of poly(ADP-ribose) neurotoxicity: three hypotheses.

Alberto Chiarugi1.   

Abstract

Poly(ADP-ribose) (PAR) is a branched and negatively charged polymeric macromolecule formed by poly(ADP-ribose) polymerases. Targeting of PAR onto acceptor proteins affects their functioning and regulates cellular homeostasis. A large body of evidence demonstrates that increased neo-formation of PAR has a crucial role in neurodegeneration. Consistently, strategies aimed at reducing PAR synthesis are of therapeutic relevance to treatment of several experimental neurodegenerative diseases. However, how PAR causes neuronal death is still elusive. This review provides an appraisal of the possible molecular mechanisms underlying PAR neurotoxicity, highlighting the pleiotypic effects of the polymer on neural cells exposed to different stressful conditions.

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Year:  2005        PMID： 15923038     DOI： 10.1016/j.neuro.2005.01.012

Source DB:  PubMed          Journal:  Neurotoxicology        ISSN： 0161-813X            Impact factor:   4.294


  14 in total

1.  Kainate-mediated excitotoxicity induces neuronal death in the rat spinal cord in vitro via a PARP-1 dependent cell death pathway (Parthanatos).

Authors:  Anujaianthi Kuzhandaivel; Andrea Nistri; Miranda Mladinic
Journal:  Cell Mol Neurobiol       Date:  2010-05-26       Impact factor: 5.046

Review 2.  Interplay between NAD+ and acetyl‑CoA metabolism in ischemia-induced mitochondrial pathophysiology.

Authors:  Nina Klimova; Aaron Long; Susana Scafidi; Tibor Kristian
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2018-09-24       Impact factor: 5.187

Review 3.  Oxidative and nitrative stress in neurodegeneration.

Authors:  Catherine A Cobb; Marsha P Cole
Journal:  Neurobiol Dis       Date:  2015-05-27       Impact factor: 5.996

4.  Anti-inflammatory effects of PJ34, a poly(ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice.

Authors:  M Haddad; H Rhinn; C Bloquel; B Coqueran; C Szabó; M Plotkine; D Scherman; I Margaill
Journal:  Br J Pharmacol       Date:  2006-07-24       Impact factor: 8.739

Review 5.  Molecular Mechanisms of Parthanatos and Its Role in Diverse Diseases.

Authors:  Ping Huang; Guangwei Chen; Weifeng Jin; Kunjun Mao; Haitong Wan; Yu He
Journal:  Int J Mol Sci       Date:  2022-06-30       Impact factor: 6.208

Review 6.  Mitochondrial dysfunction and NAD(+) metabolism alterations in the pathophysiology of acute brain injury.

Authors:  Katrina Owens; Ji H Park; Rosemary Schuh; Tibor Kristian
Journal:  Transl Stroke Res       Date:  2013-08-10       Impact factor: 6.829

Review 7.  The importance of NAD in multiple sclerosis.

Authors:  W Todd Penberthy; Ikuo Tsunoda
Journal:  Curr Pharm Des       Date:  2009       Impact factor: 3.116

8.  Oral poly(ADP-ribose) polymerase-1 inhibitor BSI-401 has antitumor activity and synergizes with oxaliplatin against pancreatic cancer, preventing acute neurotoxicity.

Authors:  Davide Melisi; Valeria Ossovskaya; Cihui Zhu; Roberta Rosa; Jianhua Ling; Patrick M Dougherty; Barry M Sherman; James L Abbruzzese; Paul J Chiao
Journal:  Clin Cancer Res       Date:  2009-10-06       Impact factor: 12.531

9.  Hyperactivation of PARP triggers nonhomologous end-joining in repair-deficient mouse fibroblasts.

Authors:  Natalie R Gassman; Donna F Stefanick; Padmini S Kedar; Julie K Horton; Samuel H Wilson
Journal:  PLoS One       Date:  2012-11-07       Impact factor: 3.240

Review 10.  Parthanatos, a messenger of death.

Authors:  Karen Kate David; Shaida Ahmad Andrabi; Ted Murray Dawson; Valina Lynn Dawson
Journal:  Front Biosci (Landmark Ed)       Date:  2009-01-01
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