AIMS: We evaluated the clinicopathologic relevance of plasma osteopontin (OPN) level in nasopharyngeal carcinoma patients. METHODS: Seventy-two plasma samples were collected from patients with undifferentiated nasopharyngeal carcinoma (NPC) before radiotherapy. Plasma OPN level was determined by quantitative sandwich enzyme immunoassay. The plasma OPN level was evaluated for its clinicopathologic relevance. RESULTS: The mean plasma OPN level was significantly higher in NPC patients than in normal controls (184.66 vs 75.89 ng/ml, p<0.001). In addition, high OPN level was found in the patients with advanced cancer and was correlated with neck node metastasis (p<0.05). CONCLUSIONS: Our findings indicated a potential role of OPN in the pathogenesis and nodal metastasis of undifferentiated NPC.
AIMS: We evaluated the clinicopathologic relevance of plasma osteopontin (OPN) level in nasopharyngeal carcinomapatients. METHODS: Seventy-two plasma samples were collected from patients with undifferentiated nasopharyngeal carcinoma (NPC) before radiotherapy. Plasma OPN level was determined by quantitative sandwich enzyme immunoassay. The plasma OPN level was evaluated for its clinicopathologic relevance. RESULTS: The mean plasma OPN level was significantly higher in NPC patients than in normal controls (184.66 vs 75.89 ng/ml, p<0.001). In addition, high OPN level was found in the patients with advanced cancer and was correlated with neck node metastasis (p<0.05). CONCLUSIONS: Our findings indicated a potential role of OPN in the pathogenesis and nodal metastasis of undifferentiated NPC.
Authors: Azizbek Ramankulov; Michael Lein; Glen Kristiansen; Hellmuth-A Meyer; Stefan A Loening; Klaus Jung Journal: J Cancer Res Clin Oncol Date: 2007-05-04 Impact factor: 4.553
Authors: Dirk Vordermark; Harun M Said; Astrid Katzer; Thomas Kuhnt; Gabriele Hänsgen; Jürgen Dunst; Michael Flentje; Matthias Bache Journal: BMC Cancer Date: 2006-08-15 Impact factor: 4.430
Authors: Alexander Rühle; Anca-L Grosu; Nicole Wiedenmann; Juri Ruf; Birgit Bieber; Raluca Stoian; Andreas R Thomsen; Eleni Gkika; Peter Vaupel; Dimos Baltas; Wolfgang A Weber; Michael Mix; Nils H Nicolay Journal: Clin Transl Radiat Oncol Date: 2022-02-21