| Literature DB >> 15922837 |
John A Hadfield1, Keira Gaukroger, Nicholas Hirst, Anna P Weston, Nicholas J Lawrence, Alan T McGown.
Abstract
A series of combretastatins substituted with epoxides, amides and small alkyl groups has been synthesised and evaluated for cytotoxicity and their ability to inhibit the assembly of tubulin. The methyl and ethyl substituted phenols 36, 44 have shown potent antimitotic effects whilst exhibiting reduced cytotoxicity.Entities:
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Year: 2005 PMID： 15922837 DOI： 10.1016/j.ejmech.2004.12.008
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514