BACKGROUND: The development of heart failure after acute myocardial infarction (AMI) has been shown to be associated with inflammation, which is positively and negatively regulated by T helper (Th) 1 and Th2 lymphocytes, respectively. Several studies have indicated that statins can improve heart function after AMI. AIMS: To study the effects of atorvastatin on Th polarization in patients with AMI. METHODS: Peripheral blood mononuclear cells were collected from 20 patients with AMI treated with oral atorvastatin (10 mg/d, group AMI-A) and 18 patients with AMI (group AMI-C) who did not receive treatment with statins. Cytokine-producing Th lymphocytes were quantified by 3-color flow cytometry. After in vitro culturing in the presence or absence of atorvastatin (0, 0.3, 1 and 3 micromol/L) for 6 days, cytokine-producing Th lymphocytes were quantified again in AMI-C group. RESULTS: The ratio of IFN-gamma-producing T cells was significantly higher in AMI-C group (17.8% +/- 6.4%) than in the AMI patients treated with oral atorvastatin (AMI-A, 13.1% +/- 4.6%). In vitro culturing with atorvastatin significantly reduced Th1 development in the AMI-C group. There was no significant difference on the frequencies of interleukin (IL)-4-producing T cells between each group. CONCLUSIONS: Atorvastatin can reduce Th1 development but has no effect on Th2 cell-functions in AMI patients. Our findings suggest that atorvastatin can regulate the polarization of Th1/Th2, this may be one of the mechanisms through which atorvastatin improves heart function after AMI.
BACKGROUND: The development of heart failure after acute myocardial infarction (AMI) has been shown to be associated with inflammation, which is positively and negatively regulated by T helper (Th) 1 and Th2 lymphocytes, respectively. Several studies have indicated that statins can improve heart function after AMI. AIMS: To study the effects of atorvastatin on Th polarization in patients with AMI. METHODS: Peripheral blood mononuclear cells were collected from 20 patients with AMI treated with oral atorvastatin (10 mg/d, group AMI-A) and 18 patients with AMI (group AMI-C) who did not receive treatment with statins. Cytokine-producing Th lymphocytes were quantified by 3-color flow cytometry. After in vitro culturing in the presence or absence of atorvastatin (0, 0.3, 1 and 3 micromol/L) for 6 days, cytokine-producing Th lymphocytes were quantified again in AMI-C group. RESULTS: The ratio of IFN-gamma-producing T cells was significantly higher in AMI-C group (17.8% +/- 6.4%) than in the AMI patients treated with oral atorvastatin (AMI-A, 13.1% +/- 4.6%). In vitro culturing with atorvastatin significantly reduced Th1 development in the AMI-C group. There was no significant difference on the frequencies of interleukin (IL)-4-producing T cells between each group. CONCLUSIONS:Atorvastatin can reduce Th1 development but has no effect on Th2 cell-functions in AMI patients. Our findings suggest that atorvastatin can regulate the polarization of Th1/Th2, this may be one of the mechanisms through which atorvastatin improves heart function after AMI.
Authors: Lilian Melo; Ivo Santana Caldas; Maíra Araújo Azevedo; Karolina Ribeiro Gonçalves; Alvaro Fernando da Silva do Nascimento; Vivian Paulino Figueiredo; Lívia de Figueiredo Diniz; Wanderson Geraldo de Lima; Rosália Moraes Torres; Maria Terezinha Bahia; André Talvani Journal: Am J Trop Med Hyg Date: 2011-02 Impact factor: 2.345
Authors: Nevena D Draginic; Vladimir L Jakovljevic; Jovana N Jeremic; Ivan M Srejovic; Marijana M Andjic; Marina R Rankovic; Jasmina Z Sretenovic; Vladimir I Zivkovic; Biljana T Ljujic; Slobodanka L Mitrovic; Stefani S Bolevich; Sergey B Bolevich; Isidora M Milosavljevic Journal: Oxid Med Cell Longev Date: 2022-02-28 Impact factor: 6.543