| Literature DB >> 15922600 |
Jérôme Govin1, Cécile Caron, Sophie Rousseaux, Saadi Khochbin.
Abstract
Histone variants functionally differentiate individual nucleosomes and, hence, act as key regulators of chromatin structure and function. Large-scale proteomic projects are now valuable sources of histone-variant discovery, showing, in particular, that somatic mammalian cells express a larger panel of histone H3 variants than previously thought, including testis-specific variants and as yet uncharacterized species. These data also suggest a tight relationship between the complexity of histone-variant expression and physiopathological states of the cells.Entities:
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Year: 2005 PMID： 15922600 DOI： 10.1016/j.tibs.2005.05.001
Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807