Literature DB >> 15922507

Melanoma cell lines are responsive in vitro to lipopolysaccharide and express TLR-4.

Monica Molteni1, Deborah Marabella, Chiara Orlandi, Carlo Rossetti.   

Abstract

Endotoxin/lipopolysacccharide (LPS) is a potent inflammatory stimulus, which acts on tumour infiltrating leukocytes by eliciting a wide range of factors promoting invasion and metastasis. Less known is the effect of LPS directly on tumour cells. In this study, we analysed whether tumour cell lines from different origin (melanoma, ovarian carcinoma, neuroblastoma) are responsive to LPS in vitro. Results showed that only melanoma cells significantly up-regulated the production of IL-8 and cell adhesion, when triggered with LPS. These effects were associated with the constitutive expression of TLR-4 mRNA in these cells and the expression on the cell membrane of the complete LPS-binding receptor.

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Year:  2006        PMID： 15922507     DOI： 10.1016/j.canlet.2005.04.006

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  30 in total

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8.  Augmentation of therapeutic responses in melanoma by inhibition of IRAK-1,-4.

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Journal:  Mol Biol Rep       Date:  2009-08-13       Impact factor: 2.316

10.  TLR4 signaling induced by lipopolysaccharide or paclitaxel regulates tumor survival and chemoresistance in ovarian cancer.

Authors:  M Szajnik; M J Szczepanski; M Czystowska; E Elishaev; M Mandapathil; E Nowak-Markwitz; M Spaczynski; T L Whiteside
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