| Literature DB >> 1592225 |
S Evangelista1, D Renzi, P Guzzi, C Surrenti, P Santicioli, C A Maggi.
Abstract
1. N-Ethylmaleimide (NEM) and capsaicin induced a release of calcitonin gene-related peptide-like immunoreactivity (CGRP-li) in superfusates from rat gastric corpus. 2. The prior application of capsaicin completely blocked CGRP-li release by NEM while the exposure to NEM reduced the capsaicin-evoked CGRP-li outflow by about 51%. 3. These findings provide evidence that NEM might exert capsaicin-like activity in rat stomach and the release of CGRP-li from capsaicin-sensitive afferent fibres might influence the properties exerted by NEM in this tissue.Entities:
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Year: 1992 PMID： 1592225 DOI： 10.1016/0306-3623(92)90044-k
Source DB: PubMed Journal: Gen Pharmacol ISSN： 0306-3623