| Literature DB >> 15921764 |
Maria Diedrichs-Möhring1, Peter J Nelson, Amanda E I Proudfoot, Stephan R Thurau, Gerhild Wildner.
Abstract
Lymphocyte trafficking is controlled in part by the actions of chemokines. In rat experimental autoimmune uveitis (EAU) we observed differential therapeutic effects of Met-RANTES, a CCR1/CCR5 receptor antagonist, depending on the retinal antigen peptides inducing the disease and the time of application during the afferent or efferent immune response. CCR1 and/or CCR5 blockade may have inhibitory effects on different phases of the autoimmune response, depending on the antigen specificity of T cells in EAU. In contrast, Met-RANTES enhanced therapeutic oral tolerance independently of orally applied antigen.Entities:
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Year: 2005 PMID： 15921764 DOI： 10.1016/j.jneuroim.2005.02.023
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478