Literature DB >> 1592158

Fasting induced alterations in mitochondrial palmitoyl-CoA metabolism may inhibit adipocyte pyruvate dehydrogenase activity.

K H Moore1, D M Dandurand, F L Kiechle.   

Abstract

1. Adipocytes from fed and fasted (24 hr) groups of rats were fractionated into mitochondria, microsomes and plasma membranes. 2. Fasting significantly decreased the mitochondrial activity of palmitoyl-CoA synthetase, palmitoyl-CoA hydrolase, beta-oxidation and pyruvate dehydrogenase. 3. Fasting elevated intramitochondrial long-chain acyl-CoA. 4. Pyruvate dehydrogenase was inhibited 50% by addition of 30 microM palmitoyl-CoA. 5. Fasting-induced changes in palmitoyl-CoA metabolism may modulate pyruvate dehydrogenase activity in adipocyte mitochondria.

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Year:  1992        PMID： 1592158     DOI： 10.1016/0020-711x(92)90017-u

Source DB:  PubMed          Journal:  Int J Biochem        ISSN： 0020-711X


  10 in total

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5.  Lactic acidosis and mitochondrial dysfunction in two children with peroxisomal disorders.

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6.  Interaction of acyl-CoA binding protein (ACBP) on processes for which acyl-CoA is a substrate, product or inhibitor.

Authors:  J T Rasmussen; J Rosendal; J Knudsen
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7.  Focal impairment in myocardial fatty acid imaging in the left anterior descending artery area, a strong predictor for cardiac death in hemodialysis patients without obstructive coronary artery disease.

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9.  Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes.

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10.  High activity of fatty acid oxidation enzymes in human placenta: implications for fetal-maternal disease.

Authors:  N A Oey; M E J den Boer; J P N Ruiter; R J A Wanders; M Duran; H R Waterham; K Boer; J A M van der Post; F A Wijburg
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  10 in total

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