| Literature DB >> 15921417 |
Bharat P Bashyal1, E M Kithsiri Wijeratne, Stanley H Faeth, A A Leslie Gunatilaka.
Abstract
Three new esters of orsellinic acid, globosumones A-C (1-3), and three known compounds, orsellinic acid (4), orcinol, and trichodion (5), were isolated from Chaetomium globosum endophytic on Ephedrafasciculata (Mormon tea). The structures of the new compounds 1-3 were established spectroscopically, which included 2D NMR experiments and 1H NMR studies on Mosher's ester derivatives. All compounds were evaluated for inhibition of cell proliferation in a panel of four cancer cell lines, NCI-H460 (non-small cell lung cancer), MCF-7 (breast cancer), SF-268 (CNS glioma), and MIA Pa Ca-2 (pancreatic carcinoma), and normal human fibroblast cells (WI-38). Only globosumones A (1) and B (2) were found to be moderately active.Entities:
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Year: 2005 PMID： 15921417 DOI： 10.1021/np058014b
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050