| Literature DB >> 15921414 |
Thein Zaw Linn1, Suresh Awale, Yasuhiro Tezuka, Arjun H Banskota, Surya K Kalauni, Faisal Attamimi, Jun-Ya Ueda, Puji Budi Setia Asih, Din Syafruddin, Ken Tanaka, Shigetoshi Kadota.
Abstract
The CH2Cl2 extract of the seed kernels of Caesalpinia crista, which exhibited promising antimalarial activity against Plasmodium berghei-infected mice in vivo, was examined and resulted in the isolation of seven new furanocassane-type diterpenes [caesalpinins C-G (1-5) and norcaesalpinins D and E (6, 7)] together with norcaesalpinins A-C (8-10) and 11 known compounds (norcaesalpinins A-C, 2-acetoxy-3-deacetoxycaesaldekarin e, caesalmin B, caesaldekarin e, caesalpin F, 14(17)-dehydrocaesalpin F, 2-acetoxycaesaldekarin e, 7-acetoxybonducellpin C, and caesalmin G). Their structures were determined on the basis of spectroscopic analysis. The isolated diterpenes showed significant dose-dependent inhibitory effects on Plasmodium falciparum FCR-3/A2 growth in vitro. Their IC50 values ranged from 90 nM to 6.5 microM, and norcaesalpinin E (7) showed the most potent inhibitory activity (IC50, 90 nM).Entities:
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Year: 2005 PMID： 15921414 DOI： 10.1021/np0401720
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050