Literature DB >> 15921403

Cytotoxic cembranoid diterpenes from a soft coral Sinularia gibberosa.

Guoqiang Li1, Yanling Zhang, Zhiwei Deng, Leen van Ofwegen, Peter Proksch, Wenhan Lin.   

Abstract

Five new alpha-methylene-gamma-lactone-bearing cembranoid diterpenes, sinularolides A-E (1-5), along with 10 known cembranoids, were isolated from the soft coral Sinularia gibberosa. Their structures were determined by extensive spectroscopic (IR, MS, 2D NMR) data analysis. Compounds 2-5 showed moderate activity against selected tumor cell lines.

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Year:  2005        PMID： 15921403     DOI： 10.1021/np040197z

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  14 in total

1.  Achmatowicz Reaction and its Application in the Syntheses of Bioactive Molecules.

Authors:  Arun K Ghosh; Margherita Brindisi
Journal:  RSC Adv       Date:  2016-11-24       Impact factor: 3.361

2.  Lobolide, a diterpene, blockades the NF-κB pathway and p38 and ERK MAPK activity in macrophages in vitro.

Authors:  Xiao-fen Lv; Si-han Chen; Jie Li; Jian-ping Fang; Yue-wei Guo; Kan Ding
Journal:  Acta Pharmacol Sin       Date:  2012-08-27       Impact factor: 6.150

Review 3.  Bioactive compounds from marine invertebrates as potent anticancer drugs: the possible pharmacophores modulating cell death pathways.

Authors:  Srimanta Patra; Prakash Priyadarshi Praharaj; Debasna Pritimanjari Panigrahi; Biswajit Panda; Chandra Sekhar Bhol; Kewal Kumar Mahapatra; Soumya Ranjan Mishra; Bishnu Prasad Behera; Mrutyunjay Jena; Gautam Sethi; Shankargouda Patil; Samir Kumar Patra; Sujit Kumar Bhutia
Journal:  Mol Biol Rep       Date:  2020-08-14       Impact factor: 2.316

4.  New cembranolides from the Dongsha Atoll soft coral Lobophytum durum.

Authors:  Shi-Yie Cheng; Pei-Wen Chen; Hwa-Pyng Chen; Shang-Kwei Wang; Chang-Yih Duh
Journal:  Mar Drugs       Date:  2011-07-27       Impact factor: 6.085

Review 5.  Cnidarians as a source of new marine bioactive compounds--an overview of the last decade and future steps for bioprospecting.

Authors:  Joana Rocha; Luisa Peixe; Newton C M Gomes; Ricardo Calado
Journal:  Mar Drugs       Date:  2011-10-10       Impact factor: 6.085

6.  Sarcocrassocolides M-O, bioactive cembranoids from the Dongsha Atoll soft coral Sarcophyton crassocaule.

Authors:  Wan-Yu Lin; Yi Lu; Bo-Wei Chen; Chiung-Yao Huang; Jui-Hsin Su; Zhi-Hong Wen; Chang-Feng Dai; Yao-Haur Kuo; Jyh-Horng Sheu
Journal:  Mar Drugs       Date:  2012-03-08       Impact factor: 6.085

7.  NMR-based metabolomic analysis of spatial variation in soft corals.

Authors:  Qing He; Ruiqi Sun; Huijuan Liu; Zhufeng Geng; Dawei Chen; Yinping Li; Jiao Han; Wenhan Lin; Shushan Du; Zhiwei Deng
Journal:  Mar Drugs       Date:  2014-03-28       Impact factor: 5.118

8.  Sinulolides A-H, new cyclopentenone and butenolide derivatives from soft coral Sinularia sp.

Authors:  Bin Yang; Xiaoyi Wei; Jingxia Huang; Xiuping Lin; Juan Liu; Shengrong Liao; Junfeng Wang; Xuefeng Zhou; Lishu Wang; Yonghong Liu
Journal:  Mar Drugs       Date:  2014-10-23       Impact factor: 5.118

9.  New cembrane diterpenoids from a Hainan soft coral Sinularia sp.

Authors:  Bin Yang; Xuefeng Zhou; Hui Huang; Xian-Wen Yang; Juan Liu; Xiuping Lin; Xiubao Li; Yan Peng; Yonghong Liu
Journal:  Mar Drugs       Date:  2012-09-18       Impact factor: 6.085

10.  Bioactive cembrane derivatives from the Indian Ocean soft coral, Sinularia kavarattiensis.

Authors:  Katja-Emilia Lillsunde; Carmen Festa; Harshada Adel; Simona De Marino; Valter Lombardi; Supriya Tilvi; Dorota A Nawrot; Angela Zampella; Lisette D'Souza; Maria Valeria D'Auria; Päivi Tammela
Journal:  Mar Drugs       Date:  2014-07-03       Impact factor: 5.118
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