Literature DB >> 1592106

Comment to Shinohara et al. (1991) FEBS Letters 293, 173-174. The uncoupling protein is not expressed in rat liver.

D Ricquier1, S Raimbault, O Champigny, B Miroux, F Bouillaud.   

Abstract

Using Northern blot analysis, immunoblotting with purified antibodies and Polymerase Chain Reaction analysis, we were unable to detect the Uncoupling Protein-UCP or its mRNA in liver of control, cold-exposed or newborn rats. The unique expression of this protein in brown adipocytes was confirmed. These data refute the surprising recent report on UCP expression in rat liver (Shinohara (1991) FEBS Lett. 293, 173-174). Moreover we report that the hybridization signal obtained by these authors is probably non-specific and due to the 3' non-coding domain of the UCP cDNA probe.

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Year:  1992        PMID： 1592106     DOI： 10.1016/0014-5793(92)80496-4

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  4 in total

1.  Expression of uncoupling protein in skeletal muscle and white fat of obese mice treated with thermogenic beta 3-adrenergic agonist.

Authors:  I Nagase; T Yoshida; K Kumamoto; T Umekawa; N Sakane; H Nikami; T Kawada; M Saito
Journal:  J Clin Invest       Date:  1996-06-15       Impact factor: 14.808

Review 2.  Cardiolipins and mitochondrial proton-selective leakage.

Authors:  F L Hoch
Journal:  J Bioenerg Biomembr       Date:  1998-12       Impact factor: 2.945

3.  CCAAT/enhancer-binding proteins alpha and beta in brown adipose tissue: evidence for a tissue-specific pattern of expression during development.

Authors:  C Manchado; P Yubero; O Viñas; R Iglesias; F Villarroya; T Mampel; M Giralt
Journal:  Biochem J       Date:  1994-09-15       Impact factor: 3.857

4.  Tissue distribution of beta 3-adrenergic receptor mRNA in man.

Authors:  S Krief; F Lönnqvist; S Raimbault; B Baude; A Van Spronsen; P Arner; A D Strosberg; D Ricquier; L J Emorine
Journal:  J Clin Invest       Date:  1993-01       Impact factor: 14.808
  4 in total

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