Literature DB >> 15919212

Molecular cloning and characterization of rat CCL9 (MIP-1gamma), the ortholog of mouse CCL9.

Meiheng Yang1, Paul R Odgren.   

Abstract

We identified an EST sequence that was up-regulated during osteoclast formation in the rat. Investigating further, we cloned the cDNA from rat long bone and found it to be highly homologous to the mouse CC chemokine, CCL9, both at the nucleotide and amino acid levels. The rat CCL9 amino acid sequence is 74% identical to the mouse sequence, with an additional 11% similar amino acids. Recombinant rat CCL9 was used in chemotaxis assays of rat bone marrow cells and it was found to have a strong and dose-dependent effect. In addition, CCL9 mRNA was very highly up-regulated during osteoclast differentiation of rat bone marrow-derived mononuclear cells, increasing by over 100-fold when stimulated by colony stimulating factor-1 and the TNF superfamily member, RANKL. Together, these results establish that, like the mouse, the rat also uses CCL9 to promote the complex process of osteoclast formation.

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Year:  2005        PMID： 15919212     DOI： 10.1016/j.cyto.2005.04.001

Source DB:  PubMed          Journal:  Cytokine        ISSN： 1043-4666            Impact factor:   3.861


  7 in total

1.  Chemokine and chemokine receptor expression during colony stimulating factor-1-induced osteoclast differentiation in the toothless osteopetrotic rat: a key role for CCL9 (MIP-1gamma) in osteoclastogenesis in vivo and in vitro.

Authors:  Meiheng Yang; Geneviève Mailhot; Carole A MacKay; April Mason-Savas; Justin Aubin; Paul R Odgren
Journal:  Blood       Date:  2005-11-22       Impact factor: 22.113

2.  Identifying the molecular and cellular signature of cardiac dilation following myocardial infarction.

Authors:  Merry L Lindsey; Yonggang Ma; Elizabeth R Flynn; Michael D Winniford; Michael E Hall; Kristine Y DeLeon-Pennell
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2018-09-20       Impact factor: 5.187

3.  Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model.

Authors:  Takanori Kitamura; Teruaki Fujishita; Pius Loetscher; Laszlo Revesz; Hiroki Hashida; Shinae Kizaka-Kondoh; Masahiro Aoki; Makoto M Taketo
Journal:  Proc Natl Acad Sci U S A       Date:  2010-06-29       Impact factor: 11.205

4.  Expression of migration-related genes is progressively upregulated in murine Lineage-Sca-1+c-Kit+ population from the fetal to adult stages of development.

Authors:  Jesús Ciriza; Marcos E García-Ojeda
Journal:  Stem Cell Res Ther       Date:  2010-05-20       Impact factor: 6.832

5.  Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation.

Authors:  Meiheng Yang; Mark J Birnbaum; Carole A MacKay; April Mason-Savas; Benjamin Thompson; Paul R Odgren
Journal:  J Cell Physiol       Date:  2008-05       Impact factor: 6.384

6.  Lysine acetyltransferase PCAF is a key regulator of arteriogenesis.

Authors:  Antonius J N M Bastiaansen; Mark M Ewing; Hetty C de Boer; Tineke C van der Pouw Kraan; Margreet R de Vries; Erna A B Peters; Sabine M J Welten; Ramon Arens; Scott M Moore; James E Faber; J Wouter Jukema; Jaap F Hamming; A Yaël Nossent; Paul H A Quax
Journal:  Arterioscler Thromb Vasc Biol       Date:  2013-06-20       Impact factor: 8.311

7.  Sympathetic Nervous System Control of Carbon Tetrachloride-Induced Oxidative Stress in Liver through α-Adrenergic Signaling.

Authors:  Jung-Chun Lin; Yi-Jen Peng; Shih-Yu Wang; Mei-Ju Lai; Ton-Ho Young; Donald M Salter; Herng-Sheng Lee
Journal:  Oxid Med Cell Longev       Date:  2015-12-21       Impact factor: 6.543
  7 in total

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