Literature DB >> 15918826

In vitro effects of gelatin solutions on platelet function: a comparison with hydroxyethyl starch solutions.

U Thaler1, E Deusch, S A Kozek-Langenecker.   

Abstract

The aim of this study was to investigate the effects of various gelatin and hydroxyethyl starch solutions on platelet reactivity. Citrated whole blood was obtained from 20 healthy volunteers. Expression of glycoprotein (GP) IIb-IIIa and p-selectin were determined using whole blood flow cytometry on both resting and agonist-activated platelets before and after in vitro haemodilution (20% and 40%) using oxypolygelatin, modified gelatin, urea-linked gelatin, hydroxyethyl starch (HES) 130 (mean molecular weight in kDa), HES 200, HES 450 and HES 550. High degrees of haemodilution using oxypolygelatin had no significant effect, similar to HES 130, whereas modified gelatin inhibited GP IIb-IIIa expression, similar to HES 200 and HES 450. Urea-linked gelatin significantly increased the expression of GP IIb-IIIa, similar to HES 550. p-selectin expression remained unchanged in all samples. The present in vitro study indicates that chemical characteristics of colloidal solutions modulate their influence on platelet reactivity.

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Year:  2005        PMID： 15918826     DOI： 10.1111/j.1365-2044.2005.04184.x

Source DB:  PubMed          Journal:  Anaesthesia        ISSN： 0003-2409            Impact factor:   6.955


  6 in total

1.  Comparison of two different coagulation algorithms on the use of allogenic blood products and coagulation factors in severely injured trauma patients: a retrospective, multicentre, observational study.

Authors:  Alexander Kaserer; Mattias Casutt; Kai Sprengel; Burkhardt Seifert; Donat R Spahn; Philipp Stein
Journal:  Scand J Trauma Resusc Emerg Med       Date:  2018-01-08       Impact factor: 2.953

Review 2.  Intravenous Fluid Administration and the Coagulation System.

Authors:  Corrin J Boyd; Benjamin M Brainard; Lisa Smart
Journal:  Front Vet Sci       Date:  2021-04-15

3.  Combined Administration of Fibrinogen and Factor XIII Concentrate Does Not Improve Dilutional Coagulopathy Superiorly Than Sole Fibrinogen Therapy: Results of an In-Vitro Thrombelastographic Study.

Authors:  Emmanuel Schneck; Marcus Muelich; Melanie Markmann; Fabian Edinger; Nina Cooper; Annette Moeller; Gregor Bein; Andreas Hecker; Christian Koch; Michael Sander; Matthias Wolff
Journal:  J Clin Med       Date:  2021-05-12       Impact factor: 4.241

4.  Assessment of hemostatic changes after crystalloid and colloid fluid preloading in trauma patients using standard coagulation parameters and thromboelastography.

Authors:  Chhavi Sawhney; Arulselvi Subramanian; Manpreet Kaur; Ajaz Anjum; Venencia Albert; Kapil Dev Soni; Ajit Kumar
Journal:  Saudi J Anaesth       Date:  2013-01

5.  In vitro norepinephrine significantly activates isolated platelets from healthy volunteers and critically ill patients following severe traumatic brain injury.

Authors:  Christoph Tschuor; Lars M Asmis; Philipp M Lenzlinger; Martina Tanner; Luc Härter; Marius Keel; Reto Stocker; John F Stover
Journal:  Crit Care       Date:  2008-06-18       Impact factor: 9.097

6.  Hypocoagulability and Platelet Dysfunction Are Exacerbated by Synthetic Colloids in a Canine Hemorrhagic Shock Model.

Authors:  Corrin J Boyd; Melissa A Claus; Anthea L Raisis; Giselle Hosgood; Claire R Sharp; Lisa Smart
Journal:  Front Vet Sci       Date:  2018-11-13
  6 in total

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