| Literature DB >> 15918578 |
K Kettler1, J Sakowski, J Wiesner, R Ortmann, H Jomaa, M Schlitzer.
Abstract
Through the combination of nitrophenylfurylacryloyl moiety which has been designed to occupy an aryl binding site of farnesyltransferase with several AA(X)-peptidomimetic substructures some novel farnesyltransferase inhibitors were obtained. Evaluation of their antimalarial activity and some initial modifications yielded a 4-benzophenone- and a sulfonamid-based novel lead for antimalarial farnesyltransferase inhibitors.Entities:
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Year: 2005 PMID： 15918578 DOI： 10.1002/chin.200536090
Source DB: PubMed Journal: Pharmazie ISSN： 0031-7144 Impact factor: 1.267