Literature DB >> 15917880

Therapeutic potential of novel Na+-Ca2+ exchange inhibitors in attenuating ischemia-reperfusion injury.

Candace Lee1, Naranjan S Dhalla, Larry V Hryshko.   

Abstract

The cardiac Na+-Ca2+ exchanger (NCX) plays an essential role in regulating Ca2+ under physiological and pathophysiological conditions. In its forward mode of operation, which predominates under physiological conditions, it extrudes the Ca2+ that enters the cardiac myocyte on a beat-to-beat basis. During ischemia and reperfusion, increased intracellular Na+ leads to a decrease in Ca2+ efflux and enhanced Ca2+ influx via the NCX, potentially leading to Ca2+ overload, which is one of the major pathophysiological mechanisms for ischemia-reperfusion injury. Novel NCX inhibitors discovered in recent years have shown great promise in attenuating ischemia-reperfusion injury.

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Year:  2005        PMID： 15917880

Source DB:  PubMed          Journal:  Can J Cardiol        ISSN： 0828-282X            Impact factor:   5.223


  17 in total

1.  The role of Na dysregulation in cardiac disease and how it impacts electrophysiology.

Authors:  Brian O'Rourke; Christoph Maack
Journal:  Drug Discov Today Dis Models       Date:  2007

Review 2.  Modulation of the cardiac Na+-Ca2+ exchanger by cytoplasmic protons: Molecular mechanisms and physiological implications.

Authors:  Kyle Scranton; Scott John; Ariel Escobar; Joshua I Goldhaber; Michela Ottolia
Journal:  Cell Calcium       Date:  2019-12-11       Impact factor: 6.817

Review 3.  Fibrin(ogen) and its fragments in the pathophysiology and treatment of myocardial infarction.

Authors:  Kai Zacharowski; Paula Zacharowski; Sonja Reingruber; Peter Petzelbauer
Journal:  J Mol Med (Berl)       Date:  2006-05-06       Impact factor: 4.599

4.  Probing the role of the sodium/calcium exchanger in pentylenetetrazole-induced generalized seizures in rats.

Authors:  Prosper N'Gouemo
Journal:  Brain Res Bull       Date:  2012-09-17       Impact factor: 4.077

5.  Inhibitory effect of YM-244769, a novel Na+/Ca2+ exchanger inhibitor on Na+/Ca2+ exchange current in guinea pig cardiac ventricular myocytes.

Authors:  Kanna Yamashita; Yasuhide Watanabe; Satomi Kita; Takahiro Iwamoto; Junko Kimura
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2016-08-01       Impact factor: 3.000

Review 6.  Ca2+ regulation of ion transport in the Na+/Ca2+ exchanger.

Authors:  Mark Hilge
Journal:  J Biol Chem       Date:  2012-07-20       Impact factor: 5.157

7.  Chronic administration of KB-R7943 induces up-regulation of cardiac NCX1.

Authors:  Lin Xu; Christiana S Kappler; Santhosh K Mani; Neal R Shepherd; Ludivine Renaud; Paige Snider; Simon J Conway; Donald R Menick
Journal:  J Biol Chem       Date:  2009-08-06       Impact factor: 5.157

8.  Gene inactivation of Na+/H+ exchanger isoform 1 attenuates apoptosis and mitochondrial damage following transient focal cerebral ischemia.

Authors:  Yanping Wang; Jing Luo; Xinzhi Chen; Hai Chen; Sam W Cramer; Dandan Sun
Journal:  Eur J Neurosci       Date:  2008-07       Impact factor: 3.386

9.  Inhibition of beta-cell sodium-calcium exchange enhances glucose-dependent elevations in cytoplasmic calcium and insulin secretion.

Authors:  Kevin S C Hamming; Daniel Soliman; Nicola J Webster; Gavin J Searle; Laura C Matemisz; David A Liknes; Xiao-Qing Dai; Thomas Pulinilkunnil; Michael J Riedel; Jason R B Dyck; Patrick E Macdonald; Peter E Light
Journal:  Diabetes       Date:  2010-04-22       Impact factor: 9.461

10.  Sodium/hydrogen exchange inhibition with cariporide reduces leukocyte adhesion via P-selectin suppression during inflammation.

Authors:  U Buerke; D Pruefer; J M Carter; M Russ; A Schlitt; R Prondzinsky; J Makowski; S Rohrbach; B Niemann; C Schulze; M Dahm; C-F Vahl; K Werdan; M Buerke
Journal:  Br J Pharmacol       Date:  2008-03-10       Impact factor: 8.739
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