Literature DB >> 15917573

Utilization of target-specific, hypersensitive strains of Saccharomyces cerevisiae to determine the mode of action of antifungal compounds.

Ed T Buurman1, Beth Andrews, April E Blodgett, Jini S Chavda, Norbert F Schnell.   

Abstract

Target-specific hypersusceptible strains of Saccharomyces cerevisiae were used to screen antifungal compounds. Two novel Erg7p inhibitors were identified, providing proof of principle of the approach taken. However, observed hypersensitivities to antifungals acting via other targets imply that use of this tool to identify the mode of action requires significant deconvolution.

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Year:  2005        PMID： 15917573      PMCID： PMC1140547          DOI： 10.1128/AAC.49.6.2558-2560.2005

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  28 in total

1.  An array of target-specific screening strains for antibacterial discovery.

Authors:  Joseph A DeVito; Jonathan A Mills; Veronica G Liu; Anjana Agarwal; Christine F Sizemore; Zhongjie Yao; Daniel M Stoughton; Maria Grazia Cappiello; Maria D F S Barbosa; Lorie A Foster; David L Pompliano
Journal:  Nat Biotechnol       Date:  2002-05       Impact factor: 54.908

2.  Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene.

Authors:  Dominique Sanglard; Françoise Ischer; Michel Monod; Jacques Bille
Journal:  Microbiology (Reading)       Date:  1997-02       Impact factor: 2.777

3.  Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor.

Authors:  D Z Chen; D V Patel; C J Hackbarth; W Wang; G Dreyer; D C Young; P S Margolis; C Wu; Z J Ni; J Trias; R J White; Z Yuan
Journal:  Biochemistry       Date:  2000-02-15       Impact factor: 3.162

4.  Biochemical and genetic characterization of the action of triclosan on Staphylococcus aureus.

Authors:  C Slater-Radosti; G Van Aller; R Greenwood; R Nicholas; P M Keller; W E DeWolf; F Fan; D J Payne; D D Jaworski
Journal:  J Antimicrob Chemother       Date:  2001-07       Impact factor: 5.790

5.  The identification of myriocin-binding proteins.

Authors:  J K Chen; W S Lane; S L Schreiber
Journal:  Chem Biol       Date:  1999-04

6.  Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae.

Authors:  M S Longtine; A McKenzie; D J Demarini; N G Shah; A Wach; A Brachat; P Philippsen; J R Pringle
Journal:  Yeast       Date:  1998-07       Impact factor: 3.239

7.  Structure-activity relationships of C1 and C6 side chains of zaragozic acid A derivatives.

Authors:  M M Ponpipom; N N Girotra; R L Bugianesi; C D Roberts; G D Berger; R M Burk; R W Marquis; W H Parsons; K F Bartizal; J D Bergstom
Journal:  J Med Chem       Date:  1994-11-11       Impact factor: 7.446

8.  Sequences that regulate the divergent GAL1-GAL10 promoter in Saccharomyces cerevisiae.

Authors:  M Johnston; R W Davis
Journal:  Mol Cell Biol       Date:  1984-08       Impact factor: 4.272

9.  Specific inhibition of fungal sterol biosynthesis by SF 86-327, a new allylamine antimycotic agent.

Authors:  N S Ryder
Journal:  Antimicrob Agents Chemother       Date:  1985-02       Impact factor: 5.191

10.  Pyridines and pyrimidines mediating activity against an efflux-negative strain of Candida albicans through putative inhibition of lanosterol demethylase.

Authors:  Ed T Buurman; April E Blodgett; Kenneth G Hull; Daniel Carcanague
Journal:  Antimicrob Agents Chemother       Date:  2004-01       Impact factor: 5.191
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  3 in total

1.  Compound prioritization methods increase rates of chemical probe discovery in model organisms.

Authors:  Iain M Wallace; Malene L Urbanus; Genna M Luciani; Andrew R Burns; Mitchell K L Han; Hao Wang; Kriti Arora; Lawrence E Heisler; Michael Proctor; Robert P St Onge; Terry Roemer; Peter J Roy; Carolyn L Cummins; Gary D Bader; Corey Nislow; Guri Giaever
Journal:  Chem Biol       Date:  2011-10-28

2.  Characterization of squalene epoxidase of Saccharomyces cerevisiae by applying terbinafine-sensitive variants.

Authors:  Christoph Ruckenstuhl; Silvia Lang; Andrea Poschenel; Armin Eidenberger; Pravas Kumar Baral; Peter Kohút; Ivan Hapala; Karl Gruber; Friederike Turnowsky
Journal:  Antimicrob Agents Chemother       Date:  2006-10-16       Impact factor: 5.191

3.  The Aspergillus nidulans pkcA gene is involved in polarized growth, morphogenesis and maintenance of cell wall integrity.

Authors:  Revital Ronen; Haim Sharon; Emma Levdansky; Jacob Romano; Yona Shadkchan; Nir Osherov
Journal:  Curr Genet       Date:  2007-04-04       Impact factor: 2.695
  3 in total

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