| Literature DB >> 15916419 |
Yihui Chen1, Xiang Zheng, Mahabeer P Dobhal, Amy Gryshuk, Janet Morgan, Thomas J Dougherty, Allan Oseroff, Ravindra K Pandey.
Abstract
Pyropheophorbides and their metal complexes were synthesized to investigate their applications as nonradioactive peripheral benzodiazepine receptor (PBR) binding probes and photosensitizers for use in photodynamic therapy. They were found to be localized in mitochondria and showed significant binding to PBR. In some cases, the PBR binding values were similar to that for 17 (PK11195, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide). However, no direct correlation between 17 displacement ability and photosensitizing efficacy of photosensitizers was observed.Entities:
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Year: 2005 PMID： 15916419 DOI： 10.1021/jm050039k
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446