Literature DB >> 15915257

Compact model for multi-phase liquid-liquid flows in micro-fluidic devices.

Fabien Jousse1, Guoping Lian, Ruth Janes, John Melrose.   

Abstract

We present a compact model describing the laminar flow of viscous multiphase fluids in micro-channel networks. We apply this model to the flow of 2 immiscible fluids representing typically oil and water, in a network of micro-channels comprising one inlet for each fluid splitting into 2 branches meeting at a T-junction, where the 2 phases are combined before exiting the network through two outlets. This network is akin to an electrical "Wheatstone bridge" and represents a simplified interdigital micro-reactor, where the fluids to be mixed are separated into smaller branches and later re-combined together. We show from an analytical solution and a computational modelling that fluid flow inside this network is very sensitive to small differences in fluid resistance between the various branches of the network, which may lead to catastrophic error in fluid distribution between the various branches that can have a profound effect on mixing. These errors depend on the viscosity difference between the fluids, on the processing conditions, and also on the geometric resistance parameters of the various channels. Increasing the resistance of the distribution channels upstream of the fluid junctions allows minimisation of the distribution errors. Interaction between the fluids can also lead to transients that are orders of magnitude longer than the flooding time of the channels. This may be exploited to provide impedance-like terms in flui-logic operations.

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Year:  2005        PMID: 15915257     DOI: 10.1039/b416666c

Source DB:  PubMed          Journal:  Lab Chip        ISSN: 1473-0189            Impact factor:   6.799


  6 in total

1.  Millifluidics as a simple tool to optimize droplet networks: Case study on drop traffic in a bifurcated loop.

Authors:  William S Wang; Siva A Vanapalli
Journal:  Biomicrofluidics       Date:  2014-12-01       Impact factor: 2.800

2.  Parallel generation of uniform fine droplets at hundreds of kilohertz in a flow-focusing module.

Authors:  David Bardin; Michael R Kendall; Paul A Dayton; Abraham P Lee
Journal:  Biomicrofluidics       Date:  2013-06-18       Impact factor: 2.800

3.  Scaled-Up Production of Monodisperse, Dual Layer Microbubbles Using Multi-Array Microfluidic Module for Medical Imaging and Drug Delivery.

Authors:  Michael R Kendall; David Bardin; Roger Shih; Paul A Dayton; Abraham P Lee
Journal:  Bubble Sci Eng Technol       Date:  2012-05

4.  Agent-based simulations of complex droplet pattern formation in a two-branch microfluidic network.

Authors:  Bradford J Smith; Donald P Gaver
Journal:  Lab Chip       Date:  2009-11-27       Impact factor: 6.799

Review 5.  High-Throughput Optofluidic Acquisition of Microdroplets in Microfluidic Systems.

Authors:  Zain Hayat; Abdel I El Abed
Journal:  Micromachines (Basel)       Date:  2018-04-14       Impact factor: 2.891

6.  The Phenomenon of Drug Emulsion Carriers Compaction during Their Movement in Microstructures.

Authors:  Mariola M Błaszczyk; Jerzy Sęk; Łukasz Przybysz
Journal:  Pharmaceutics       Date:  2022-03-08       Impact factor: 6.321

  6 in total

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