OBJECTIVES: To determine the levels of resistance to ciprofloxacin among non-typhoidal salmonellae in Scotland. METHODS: Etest strips were used to determine the ciprofloxacin MICs for nalidixic acid-resistant salmonellae isolated from humans during 1993-2003. RESULTS: The percentage of nalidixic acid-resistant salmonellae isolated from human infection in Scotland has increased from 1.4% in 1993, to 8.8% in 1998 and 21.3% in 2003. Of 493 strains of nalidixic acid-resistant Salmonella tested, a single isolate of Salmonella Typhimurium RDNC was resistant to ciprofloxacin at the NCCLS breakpoint of 4 mg/L. Eleven isolates were resistant at the Scottish Salmonella Reference Laboratory breakpoint of 0.5 mg/L, while 466 isolates (94.5%) had reduced susceptibility with MICs of > or =0.125 mg/L and <0.5 mg/L. CONCLUSIONS: These results show that very few non-typhoidal isolates of Salmonella in Scotland that are resistant to nalidixic acid are also resistant to ciprofloxacin at the NCCLS recommended breakpoint of 4 mg/L. The majority of isolates examined, however, do show reduced susceptibility at 0.125 mg/L. This confirms the necessity for continuing antimicrobial surveillance of resistance to this important antibiotic.
OBJECTIVES: To determine the levels of resistance to ciprofloxacin among non-typhoidal salmonellae in Scotland. METHODS: Etest strips were used to determine the ciprofloxacin MICs for nalidixic acid-resistant salmonellae isolated from humans during 1993-2003. RESULTS: The percentage of nalidixic acid-resistant salmonellae isolated from humaninfection in Scotland has increased from 1.4% in 1993, to 8.8% in 1998 and 21.3% in 2003. Of 493 strains of nalidixic acid-resistant Salmonella tested, a single isolate of Salmonella Typhimurium RDNC was resistant to ciprofloxacin at the NCCLS breakpoint of 4 mg/L. Eleven isolates were resistant at the Scottish Salmonella Reference Laboratory breakpoint of 0.5 mg/L, while 466 isolates (94.5%) had reduced susceptibility with MICs of > or =0.125 mg/L and <0.5 mg/L. CONCLUSIONS: These results show that very few non-typhoidal isolates of Salmonella in Scotland that are resistant to nalidixic acid are also resistant to ciprofloxacin at the NCCLS recommended breakpoint of 4 mg/L. The majority of isolates examined, however, do show reduced susceptibility at 0.125 mg/L. This confirms the necessity for continuing antimicrobial surveillance of resistance to this important antibiotic.
Authors: Manar Al-Mashhadani; Robert Hewson; Roberto Vivancos; Alex Keenan; Nick J Beeching; John Wain; Christopher M Parry Journal: Emerg Infect Dis Date: 2011-01 Impact factor: 6.883
Authors: Roberta B Souza; Rafaela G Ferrari; Marciane Magnani; Luciana B M Kottwitz; Iliana Alcocer; Maria Cristina B Tognim; Tereza C R M Oliveira Journal: Braz J Microbiol Date: 2010-06-01 Impact factor: 2.476