Literature DB >> 15914003

DNA binding specificity and cytotoxicity of novel antitumor agent Ge132 derivatives.

Guoqiang Shangguan1, Feifei Xing, Xiaogang Qu, Jianhua Mao, Dan Zhao, Xuejian Zhao, Jinsong Ren.   

Abstract

A series of Ge132 derivatives have shown enhanced antitumor activity. Previous studies suggest that DNA can be their primary target. Here we show direct evidence that two newly synthesized Ge132 derivatives can intercalate into DNA. Unexpected methyl substitution effect of the novel derivatives on DNA sequence selectivity and cytotoxicity was observed.

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Year:  2005        PMID： 15914003     DOI： 10.1016/j.bmcl.2005.04.053

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Carbon nanotubes selective destabilization of duplex and triplex DNA and inducing B-A transition in solution.

Authors:  Xi Li; Yinghua Peng; Xiaogang Qu
Journal:  Nucleic Acids Res       Date:  2006-08-02       Impact factor: 16.971

2.  Synthesis, antibacterial properties and bioinformatics computational analyses of novel 8-hydroxyquinoline derivatives.

Authors:  Mohamed Rbaa; Siham Jabli; Younes Lakhrissi; Mohamed Ouhssine; Faisal Almalki; Taibi Ben Hadda; Saida Messgo-Moumene; Abbelkader Zarrouk; Brahim Lakhrissi
Journal:  Heliyon       Date:  2019-10-21

3.  Synthesis and evaluation of novel organogermanium sesquioxides as antitumor agents.

Authors:  Chun Li Zhang; Tai Hua Li; Shuang Huan Niu; Rong Fu Wang; Zhan Li Fu; Feng Qin Guo; Ming Yang
Journal:  Bioinorg Chem Appl       Date:  2009-06-02       Impact factor: 7.778

4.  Lighting up left-handed Z-DNA: photoluminescent carbon dots induce DNA B to Z transition and perform DNA logic operations.

Authors:  Lingyan Feng; Andong Zhao; Jinsong Ren; Xiaogang Qu
Journal:  Nucleic Acids Res       Date:  2013-06-27       Impact factor: 16.971
  4 in total

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