Literature DB >> 15913793

Morphine withdrawal sensitizes mice to lipopolysaccharide: elevated TNF-alpha and nitric oxide with decreased IL-12.

Pu Feng1, Joseph J Meissler, Martin W Adler, Toby K Eisenstein.   

Abstract

Mice made dependent on morphine using slow-release morphine pellets for 96 h were withdrawn by removal of pellets, followed by a sublethal dose of LPS 24 h later. These animals exhibited 100% lethality. Animals withdrawn from placebo pellets receiving LPS all survived, as did morphine-withdrawn mice receiving saline. Morphine-withdrawn LPS-treated animals had elevated serum TNF-alpha and nitric oxide levels, and depressed IL-12 levels compared to controls. Anti-TNF-alpha antibody given prior to LPS challenge afforded significant protection to morphine-withdrawn animals. These studies show that morphine withdrawal sensitizes to LPS lethality via increased production of TNF-alpha.

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Year:  2005        PMID： 15913793     DOI： 10.1016/j.jneuroim.2005.03.017

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  18 in total

Review 1.  Opioids and HIV/HCV infection.

Authors:  Xu Wang; Ting Zhang; Wen-Zhe Ho
Journal:  J Neuroimmune Pharmacol       Date:  2011-07-14       Impact factor: 4.147

Review 2.  Effects of opioid tolerance and withdrawal on the immune system.

Authors:  Toby K Eisenstein; Rahil T Rahim; Pu Feng; Nita K Thingalaya; Joseph J Meissler
Journal:  J Neuroimmune Pharmacol       Date:  2006-05-23       Impact factor: 4.147

3.  Increased sensitivity to Salmonella enterica serovar Typhimurium infection in mice undergoing withdrawal from morphine is associated with suppression of interleukin-12.

Authors:  Pu Feng; Qiana M Wilson; Joseph J Meissler; Martin W Adler; Toby K Eisenstein
Journal:  Infect Immun       Date:  2005-12       Impact factor: 3.441

Review 4.  Imaging Biomarkers of the Neuroimmune System among Substance Use Disorders: A Systematic Review.

Authors:  Eric A Woodcock; Ansel T Hillmer; Graeme F Mason; Kelly P Cosgrove
Journal:  Mol Neuropsychiatry       Date:  2019-05-09

Review 5.  Immunosuppressive effects of opioids--clinical relevance.

Authors:  Alexander Brack; Heike L Rittner; Christoph Stein
Journal:  J Neuroimmune Pharmacol       Date:  2011-07-05       Impact factor: 4.147

6.  Morphine withdrawal stress modulates lipopolysaccharide-induced interleukin 12 p40 (IL-12p40) expression by activating extracellular signal-regulated kinase 1/2, which is further potentiated by glucocorticoids.

Authors:  Subhas Das; Jennifer Kelschenbach; Richard Charboneau; Roderick A Barke; Sabita Roy
Journal:  J Biol Chem       Date:  2011-07-05       Impact factor: 5.157

7.  CCR5 mediates HIV-1 Tat-induced neuroinflammation and influences morphine tolerance, dependence, and reward.

Authors:  Maciej Gonek; Virginia D McLane; David L Stevens; Kumiko Lippold; Hamid I Akbarali; Pamela E Knapp; William L Dewey; Kurt F Hauser; Jason J Paris
Journal:  Brain Behav Immun       Date:  2017-11-13       Impact factor: 7.217

8.  Morphine withdrawal lowers host defense to enteric bacteria: spontaneous sepsis and increased sensitivity to oral Salmonella enterica serovar Typhimurium infection.

Authors:  Pu Feng; Allan L Truant; Joseph J Meissler; John P Gaughan; Martin W Adler; Toby K Eisenstein
Journal:  Infect Immun       Date:  2006-09       Impact factor: 3.441

9.  An in vitro model of morphine withdrawal manifests the enhancing effect on human immunodeficiency virus infection of human T lymphocytes through the induction of substance P.

Authors:  Xu Wang; Steven D Douglas; Jin-Song Peng; Dun-Jin Zhou; Qi Wan; Wen-Zhe Ho
Journal:  Am J Pathol       Date:  2006-11       Impact factor: 4.307

Review 10.  Intensive Care Unit-acquired infection as a side effect of sedation.

Authors:  Saad Nseir; Demosthenes Makris; Daniel Mathieu; Alain Durocher; Charles-Hugo Marquette
Journal:  Crit Care       Date:  2010-03-15       Impact factor: 9.097
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