| Literature DB >> 15913570 |
In Koo Hwang1, Dae Won Kim, Ki-Yeon Yoo, Boo-Kyoung Jung, Ji-Hyun Song, Ju-Young Jung, Soo Young Choi, Tae-Cheon Kang, Jae-Yong Lee, Young-Guen Kwon, Moo Ho Won.
Abstract
We observed chronological changes of platelet endothelial cell adhesion molecule-1 (PECAM-1), final mediator of neutrophil transendothelial migration, immunoreactivity, and protein level in the gerbil hippocampus proper after 5 min of transient ischemia. One day after ischemic insult, PECAM-1 immunoreactivity and protein level increased slightly in the hippocampus proper. Thereafter, PECAM-1 immunoreactivity and protein level increased significantly in the hippocampus proper by 4 days after ischemic insult. Especially, PECAM-1 in the hippocampal CA1 region was higher than that in the CA2/3 region. Five days after ischemic insult, PECAM-1 immunoreactivity decreased compared to the 4 days post-ischemic group. However, the RNA levels of PECAM-1 in the hippocampus proper were significantly decreased in the 4 days post-ischemic groups compared to that in the sham-operated group. This result suggests that the increase of PECAM-1 and decrease of PECAM-1 RNA in the CA1 region 4 days after ischemia may be associated with transmigration of neurotrophil.Entities:
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Year: 2005 PMID： 15913570 DOI： 10.1016/j.brainres.2005.04.049
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252