Literature DB >> 15911868

Rho family GTPases and dendrite plasticity.

Manabu Negishi1, Hironori Katoh.   

Abstract

Dendrite structures exert a profound influence on neuronal information processing. The Rho family GTPases have been implicated in the regulation of dendritic development. Among them, Rho, Rac, and Cdc42 have been characterized extensively, and Rac and Cdc42 promote dendrite growth and branching, whereas Rho acts as a negative regulator for dendrite growth. Recently, other members of Rho family GTPases, including Rnd1 and Rnd2, have also been shown to be involved in the regulation of dendrite development. Rnd1 promotes spine maturation, and Rnd2 stimulates dendrite branching through its specific effector, Rapostlin. Thus, a variety of Rho family GTPases play important roles in dendritic development.

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Year:  2005        PMID： 15911868     DOI： 10.1177/1073858404268768

Source DB:  PubMed          Journal:  Neuroscientist        ISSN： 1073-8584            Impact factor:   7.519


  40 in total

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8.  Mechanisms of psychostimulant-induced structural plasticity.

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9.  Modeling presenilin-dependent familial Alzheimer's disease: emphasis on presenilin substrate-mediated signaling and synaptic function.

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Journal:  Int J Alzheimers Dis       Date:  2010-07-20

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