Diana Paleacu1, Edna Schechtman, Rivka Inzelberg. 1. Neurology Service and Memory Clinic, Yehuda Abarbanel Mental Health Center and Sackler Faculty of Medicine, Tel-Aviv University, Israel.
Abstract
OBJECTIVE: To identify familial risk factors for hallucinations in patients with Parkinson disease (PD). METHODS: Two hundred seventy-six outpatients with PD participated in the study. The presence of hallucinations was determined using a validated questionnaire, including items regarding the occurrence of visual, auditory, or other types of hallucinations. Family history of PD and dementia was determined by a structured interview and examination of medical records and affected family members. Patients with young-onset PD (<50 years) who reported another PD patient among their siblings were tested for parkin mutations. Stepwise logistic regression was applied for the detection of risk factors. The regression model included a set of family history-related variables (family history of PD and of dementia) and a set of disease-related variables (age, age at onset of PD, stage, duration of PD and of l-dopa therapy, l-dopa dose, and number of antiparkinsonian drugs). RESULTS: Hallucinations were present in 32% of the 276 patients. Risk factors for hallucinations included Mini-Mental State Examination score (p < 0.0001) and positive family history of dementia (p = 0.0005). CONCLUSION: Family history of dementia and lower Mini-Mental State Examination scores are risk factors for hallucinations in Parkinson disease.
OBJECTIVE: To identify familial risk factors for hallucinations in patients with Parkinson disease (PD). METHODS: Two hundred seventy-six outpatients with PD participated in the study. The presence of hallucinations was determined using a validated questionnaire, including items regarding the occurrence of visual, auditory, or other types of hallucinations. Family history of PD and dementia was determined by a structured interview and examination of medical records and affected family members. Patients with young-onset PD (<50 years) who reported another PDpatient among their siblings were tested for parkin mutations. Stepwise logistic regression was applied for the detection of risk factors. The regression model included a set of family history-related variables (family history of PD and of dementia) and a set of disease-related variables (age, age at onset of PD, stage, duration of PD and of l-dopa therapy, l-dopa dose, and number of antiparkinsonian drugs). RESULTS:Hallucinations were present in 32% of the 276 patients. Risk factors for hallucinations included Mini-Mental State Examination score (p < 0.0001) and positive family history of dementia (p = 0.0005). CONCLUSION: Family history of dementia and lower Mini-Mental State Examination scores are risk factors for hallucinations in Parkinson disease.
Authors: Joel Mack; Peter Rabins; Karen Anderson; Susanne Goldstein; Stephen Grill; Elaina S Hirsch; Susan Lehmann; John T Little; Russell L Margolis; Justin Palanci; Gregory Pontone; Howard Weiss; James R Williams; Laura Marsh Journal: Am J Geriatr Psychiatry Date: 2012-02 Impact factor: 4.105
Authors: Cole D Stang; Aidan F Mullan; Emanuele Camerucci; Mania Hajeb; Pierpaolo Turcano; Peter Martin; Michelle M Mielke; Keith A Josephs; Matthew Splett; Victor Abler; Bradley F Boeve; James H Bower; Rodolfo Savica Journal: J Parkinsons Dis Date: 2022 Impact factor: 5.520