Literature DB >> 15911576

The course of malaria in mice: major histocompatibility complex (MHC) effects, but no general MHC heterozygote advantage in single-strain infections.

Claus Wedekind1, Mirjam Walker, Tom J Little.   

Abstract

A general MHC-heterozygote advantage in parasite-infected organisms is often assumed, although there is little experimental evidence for this. We tested the response of MHC-congenic mice (F2 segregants) to malaria and found the course of infection to be significantly influenced by MHC haplotype, parasite strain, and host gender. However, the MHC heterozygotes did worse than expected from the average response of the homozygotes.

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Year:  2005        PMID： 15911576      PMCID： PMC1451180          DOI： 10.1534/genetics.105.040683

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  31 in total

1.  Gene dose effects in Ir gene-controlled systems.

Authors:  M E Dorf; J H Stimpfling; B Benacerraf
Journal:  J Immunol       Date:  1979-07       Impact factor: 5.422

2.  Enhanced immunological surveillance in mice heterozygous at the H-2 gene complex.

Authors:  P C Doherty; R M Zinkernagel
Journal:  Nature       Date:  1975-07-03       Impact factor: 49.962

3.  Discrimination of MHC-derived odors by untrained mice is consistent with divergence in peptide-binding region residues.

Authors:  Lara S Carroll; Dustin J Penn; Wayne K Potts
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-12       Impact factor: 11.205

4.  Accumulated background variation among H2 mutant congenic strains: elimination through PCR-based genotyping of F2 segregants.

Authors:  L S Carroll; W K Potts
Journal:  J Immunol Methods       Date:  2001-11-01       Impact factor: 2.303

5.  HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage.

Authors:  M Carrington; G W Nelson; M P Martin; T Kissner; D Vlahov; J J Goedert; R Kaslow; S Buchbinder; K Hoots; S J O'Brien
Journal:  Science       Date:  1999-03-12       Impact factor: 47.728

6.  Susceptibility to experimental cerebral malaria induced by Plasmodium berghei ANKA in inbred mouse strains recently derived from wild stock.

Authors:  S Bagot; M Idrissa Boubou; S Campino; C Behrschmidt; O Gorgette; J-L Guénet; C Penha-Gonçalves; D Mazier; S Pied; P-A Cazenave
Journal:  Infect Immun       Date:  2002-04       Impact factor: 3.441

7.  MHC heterozygosity confers a selective advantage against multiple-strain infections.

Authors:  Dustin J Penn; Kristy Damjanovich; Wayne K Potts
Journal:  Proc Natl Acad Sci U S A       Date:  2002-08-12       Impact factor: 11.205

Review 8.  Knockout mice: simple solutions to the problems of genetic background and flanking genes.

Authors:  David P Wolfer; Wim E Crusio; Hans Peter Lipp
Journal:  Trends Neurosci       Date:  2002-07       Impact factor: 13.837

9.  Major histocompatibility complex heterozygote superiority during coinfection.

Authors:  Erin E McClelland; Dustin J Penn; Wayne K Potts
Journal:  Infect Immun       Date:  2003-04       Impact factor: 3.441

10.  Effect of human leukocyte antigen heterozygosity on infectious disease outcome: the need for allele-specific measures.

Authors:  Marc Lipsitch; Carl T Bergstrom; Rustom Antia
Journal:  BMC Med Genet       Date:  2003-01-24       Impact factor: 2.103
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  13 in total

1.  An asymmetric model of heterozygote advantage at major histocompatibility complex genes: degenerate pathogen recognition and intersection advantage.

Authors:  Rick J Stoffels; Hamish G Spencer
Journal:  Genetics       Date:  2008-02-03       Impact factor: 4.562

Review 2.  Does intra-individual major histocompatibility complex diversity keep a golden mean?

Authors:  Benno Woelfing; Arne Traulsen; Manfred Milinski; Thomas Boehm
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2009-01-12       Impact factor: 6.237

3.  Major histocompatibility complex-linked social signalling affects female fertility.

Authors:  D Burger; S Thomas; H Aepli; M Dreyer; G Fabre; E Marti; H Sieme; M R Robinson; C Wedekind
Journal:  Proc Biol Sci       Date:  2017-12-06       Impact factor: 5.349

4.  A sequence-based approach demonstrates that balancing selection in classical human leukocyte antigen (HLA) loci is asymmetric.

Authors:  Paola G Bronson; Steven J Mack; Henry A Erlich; Montgomery Slatkin
Journal:  Hum Mol Genet       Date:  2012-10-12       Impact factor: 6.150

5.  Major histocompatibility complex (MHC) heterozygote superiority to natural multi-parasite infections in the water vole (Arvicola terrestris).

Authors:  M K Oliver; S Telfer; S B Piertney
Journal:  Proc Biol Sci       Date:  2009-03-22       Impact factor: 5.349

6.  MHC-I affects infection intensity but not infection status with a frequent avian malaria parasite in blue tits.

Authors:  Helena Westerdahl; Martin Stjernman; Lars Råberg; Mimi Lannefors; Jan-Åke Nilsson
Journal:  PLoS One       Date:  2013-08-30       Impact factor: 3.240

7.  The separate and combined effects of MHC genotype, parasite clone, and host gender on the course of malaria in mice.

Authors:  Claus Wedekind; Mirjam Walker; Tom J Little
Journal:  BMC Genet       Date:  2006-11-21       Impact factor: 2.797

8.  Diverse MHC IIB allele repertoire increases parasite resistance and body condition in the Long-tailed giant rat (Leopoldamys sabanus).

Authors:  Tobias L Lenz; Konstans Wells; Martin Pfeiffer; Simone Sommer
Journal:  BMC Evol Biol       Date:  2009-11-23       Impact factor: 3.260

9.  Parental influences on pathogen resistance in brown trout embryos and effects of outcrossing within a river network.

Authors:  Emily S Clark; Rike B Stelkens; Claus Wedekind
Journal:  PLoS One       Date:  2013-02-22       Impact factor: 3.240

10.  Polarisation of major histocompatibility complex II host genotype with pathogenesis of European Brown Hare syndrome virus.

Authors:  Christos Iacovakis; Zissis Mamuris; Katerina A Moutou; Antonia Touloudi; Anne Sofie Hammer; George Valiakos; Themis Giannoulis; Costas Stamatis; Vassiliki Spyrou; Labrini V Athanasiou; Maria Kantere; Tommy Asferg; Alexios Giannakopoulos; Charlotte M Salomonsen; Dimitrios Bogdanos; Periklis Birtsas; Liljana Petrovska; Duncan Hannant; Charalambos Billinis
Journal:  PLoS One       Date:  2013-09-19       Impact factor: 3.240
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