Literature DB >> 15911280

Design and synthesis of new bis-pyridinium oxime reactivators for acetylcholinesterase inhibited by organophosphorous nerve agents.

Tae-Hyuk Kim1, Kamil Kuca, Daniel Jun, Young-Sik Jung.   

Abstract

New bis-pyridinium oxime reactivators connected with a CH(2)CH(2)OCH(2)CH(2) linker between two pyridinium rings were designed and synthesized. In the test of their potency to reactivate AChE inhibited by cyclosarin, the bis-pyridinium oxime 6b achieved reactivation potency higher than 10% at the lower concentration 10(-4)M.

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Year:  2005        PMID： 15911280     DOI： 10.1016/j.bmcl.2005.03.060

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  12 in total

1.  Two step synthesis of a non-symmetric acetylcholinesterase reactivator.

Authors:  Kamil Musilek; Kamil Kuca; Vlastimil Dohnal; Daniel Jun; Jan Marek; Vit Koleckar
Journal:  Molecules       Date:  2007-08-07       Impact factor: 4.411

2.  Fabrication of Pt-Pd@ITO grown heterogeneous nanocatalyst as efficient remediator for toxic methyl parathion in aqueous media.

Authors:  Ali Muhammad Mahar; Aamna Balouch; Farah Naz Talpur; Pirah Panah; Raj Kumar; Ameet Kumar; Abdul Hameed Pato; Dadu Mal; Sagar Kumar; Akrajas Ali Umar
Journal:  Environ Sci Pollut Res Int       Date:  2020-01-13       Impact factor: 4.223

3.  Revealing the importance of linkers in K-series oxime reactivators for tabun-inhibited AChE using quantum chemical, docking and SMD studies.

Authors:  Shibaji Ghosh; Nellore Bhanu Chandar; Kalyanashis Jana; Bishwajit Ganguly
Journal:  J Comput Aided Mol Des       Date:  2017-06-23       Impact factor: 3.686

4.  Bisquaternary pyridinium oximes: Comparison of in vitro reactivation potency of compounds bearing aliphatic linkers and heteroaromatic linkers for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase.

Authors:  Sandip B Bharate; Lilu Guo; Tony E Reeves; Douglas M Cerasoli; Charles M Thompson
Journal:  Bioorg Med Chem       Date:  2009-11-27       Impact factor: 3.641

Review 5.  Unequal efficacy of pyridinium oximes in acute organophosphate poisoning.

Authors:  Biljana Antonijevic; Milos P Stojiljkovic
Journal:  Clin Med Res       Date:  2007-03

6.  New series of monoquaternary pyridinium oximes: Synthesis and reactivation potency for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase.

Authors:  Sandip B Bharate; Lilu Guo; Tony E Reeves; Douglas M Cerasoli; Charles M Thompson
Journal:  Bioorg Med Chem Lett       Date:  2009-07-10       Impact factor: 2.823

7.  In vitro reactivation potency of acetylcholinesterase reactivators--K074 and K075--to reactivate tabun-inhibited human brain cholinesterases.

Authors:  Kamil Kuca; Jiri Cabal; Daniel Jun; Kamil Musilek
Journal:  Neurotox Res       Date:  2007-02       Impact factor: 3.911

8.  Molecular Modeling and In Vitro Studies of a Neutral Oxime as a Potential Reactivator for Acetylcholinesterase Inhibited by Paraoxon.

Authors:  Reuel L de Paula; Joyce S F D de Almeida; Samir F A Cavalcante; Arlan S Gonçalves; Alessandro B C Simas; Tanos C C Franca; Martin Valis; Kamil Kuca; Eugenie Nepovimova; José M Granjeiro
Journal:  Molecules       Date:  2018-11-12       Impact factor: 4.411

9.  Effect of several new and currently available oxime cholinesterase reactivators on tabun-intoxicated rats.

Authors:  Jana Zdarova Karasova; Jiri Kassa; Young-Sik Jung; Kamil Musilek; Miroslav Pohanka; Kamil Kuca
Journal:  Int J Mol Sci       Date:  2008-11-14       Impact factor: 6.208

10.  A comparison of the neuroprotective efficacy of newly developed oximes (K117, K127) and currently available oxime (obidoxime) in tabun-poisoned rats.

Authors:  Jiri Kassa; Jana Zdarova Karasova; Kamil Musilek; Kamil Kuca; And Young-Sik Jung
Journal:  Toxicol Mech Methods       Date:  2009-03       Impact factor: 2.987
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