| Literature DB >> 15911263 |
Pei-Pei Kung1, Luke R Zehnder, Jerry J Meng, Stanley W Kupchinsky, Donald J Skalitzky, M Catherine Johnson, Karen A Maegley, Anne Ekker, Leslie A Kuhn, Peter W Rose, Laura A Bloom.
Abstract
The structure-based design, chemical synthesis, and biological evaluation of novel MTAP substrates are described. These compounds incorporate various C5'-moieties and are shown to have different k(cat)/K(m) values compared with the natural MTAP substrate (MTA).Entities:
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Year: 2005 PMID： 15911263 DOI： 10.1016/j.bmcl.2005.03.107
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823