Literature DB >> 15911261

Design, synthesis, and evaluation of proline based melanocortin receptor ligands.

Xinrong Tian1, Timothy Field, Adam W Mazur, Frank H Ebetino, John A Wos, Doreen Crossdoersen, Beth B Pinney, Russell J Sheldon.   

Abstract

A series of proline based melanocortin ligands has been developed on the basis of initial piperazine leads by using a more conformationally rigid scaffold. A number of these novel ligands showed significant binding affinity for MC3 and MC4 receptors.

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Year:  2005        PMID: 15911261     DOI: 10.1016/j.bmcl.2005.03.120

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  3 in total

1.  Design, synthesis, and biological evaluation of a new class of small molecule peptide mimetics targeting the melanocortin receptors.

Authors:  James P Cain; Alexander V Mayorov; Minying Cai; Hui Wang; Bahar Tan; Kevin Chandler; YeonSun Lee; Ravil R Petrov; Dev Trivedi; Victor J Hruby
Journal:  Bioorg Med Chem Lett       Date:  2006-08-22       Impact factor: 2.823

Review 2.  The MC4 receptor and control of appetite.

Authors:  R A H Adan; B Tiesjema; J J G Hillebrand; S E la Fleur; M J H Kas; M de Krom
Journal:  Br J Pharmacol       Date:  2006-10-16       Impact factor: 8.739

Review 3.  Alpha-melanocyte stimulating hormone: production and degradation.

Authors:  Giuseppe D'Agostino; Sabrina Diano
Journal:  J Mol Med (Berl)       Date:  2010-07-10       Impact factor: 4.599

  3 in total

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