| Literature DB >> 15911260 |
Jeffrey A Pfefferkorn1, Richard Nugent, Rebecca J Gross, Meredith Greene, Mark A Mitchell, Matthew T Reding, Lee A Funk, Rebecca Anderson, Peter A Wells, John A Shelly, Robert Anstadt, Barry C Finzel, Melissa S Harris, Robert E Kilkuskie, Laurice A Kopta, Francis J Schwende.
Abstract
A novel series of non-nucleoside HCV NS5B polymerase inhibitors was prepared from a (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid template. Solution and solid phase analog synthesis focused on the northern region of the template combined with structure based design led to the discovery of several potent and orally bioavailable lead compounds.Entities:
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Year: 2005 PMID： 15911260 DOI： 10.1016/j.bmcl.2005.03.106
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823