| Literature DB >> 15911249 |
Corey R Hopkins1, Mark Czekaj, Steven S Kaye, Zhongli Gao, James Pribish, Henry Pauls, Guyan Liang, Keith Sides, Dona Cramer, Jennifer Cairns, Yongyi Luo, Heng-Keang Lim, Roy Vaz, Sam Rebello, Sebastian Maignan, Alain Dupuy, Magali Mathieu, Julian Levell.
Abstract
A new series of novel mast cell tryptase inhibitors is reported, which features the use of an indole structure as the hydrophobic substituent on a m-benzylaminepiperidine template. The best members of this series display good in vitro activity and excellent selectivity against other serine proteases.Entities:
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Year: 2005 PMID： 15911249 DOI： 10.1016/j.bmcl.2005.04.002
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823