Literature DB >> 15909921

Analogues of the styrylquinoline and styrylquinazoline HIV-1 integrase inhibitors: design and synthetic problems.

J Polański1, H Niedbała, R Musioł, D Tabak, B Podeszwa, R Gieleciak, A Bak, A Pałka, T Magdziarz.   

Abstract

In our work, leading to new styrylquinoline and styrylquinazoline inhibitors of HIV integrase, we analyzed virtual combinatorial library that includes these compounds. Using this method we were able to find interesting synthetic targets. We optimized synthetic procedure yielding such compounds and obtained a couple of new analogues. Their activity will be evaluated in the near future.

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Year:  2004        PMID: 15909921

Source DB:  PubMed          Journal:  Acta Pol Pharm        ISSN: 0001-6837            Impact factor:   0.330


  5 in total

1.  Experimental and theoretical study of o-substituent effect on the fluorescence of 8-hydroxyquinoline.

Authors:  Mohie E M Zayed; Reda M El-Shishtawy; Shaaban A Elroby; Abdullah Y Obaid; Zahra M Al-amshany
Journal:  Int J Mol Sci       Date:  2015-02-10       Impact factor: 5.923

2.  Investigating the activity spectrum for ring-substituted 8-hydroxyquinolines.

Authors:  Robert Musiol; Josef Jampilek; Jacek E Nycz; Matus Pesko; James Carroll; Katarina Kralova; Marcela Vejsova; Jim O'Mahony; Aidan Coffey; Anna Mrozek; Jaroslaw Polanski
Journal:  Molecules       Date:  2010-01-12       Impact factor: 4.411

Review 3.  Recent synthetic efforts in the preparation of 2-(3,4)-alkenyl (aryl) quinoline molecules towards anti-kinetoplastid agents.

Authors:  Dayana Orozco; Vladimir V Kouznetsov; Armando Bermúdez; Leonor Y Vargas Méndez; Arturo René Mendoza Salgado; Carlos Mario Meléndez Gómez
Journal:  RSC Adv       Date:  2020-01-29       Impact factor: 4.036

4.  Design, Synthesis and In Vitro Activity of Anticancer Styrylquinolines. The p53 Independent Mechanism of Action.

Authors:  Anna Mrozek-Wilczkiewicz; Ewelina Spaczynska; Katarzyna Malarz; Wioleta Cieslik; Marzena Rams-Baron; Vladimír Kryštof; Robert Musiol
Journal:  PLoS One       Date:  2015-11-23       Impact factor: 3.240

5.  Investigating biological activity spectrum for novel styrylquinazoline analogues.

Authors:  Josef Jampilek; Robert Musiol; Jacek Finster; Matus Pesko; James Carroll; Katarina Kralova; Marcela Vejsova; Jim O'Mahony; Aidan Coffey; Jiri Dohnal; Jaroslaw Polanski
Journal:  Molecules       Date:  2009-10-23       Impact factor: 4.411

  5 in total

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