Christopher Gillberg1, Mats Cederlund. 1. Department of Child and Adolescent Psychiatry, University of Göteborg, Sweden. christopher.gillberg@pediat.gu.se
Abstract
OBJECTIVE: Study familial and pre- and perinatal factors in Asperger Syndrome (AS). METHODS: One hundred boys with AS had their records reviewed. "Pathogenetic subgroups" were defined according to presence of medical syndromes/chromosomal abnormalities, indices of familiality, and pre- and perinatal risk factors predisposing to brain damage. RESULTS: No major index of pathogenetic factors was found in 13%, a syndrome/chromosomal abnormality in 8%, pre- or perinatal risk 13%, combined pre- or perinatal risk and family history in 11%, and family history only in 55%. COMMENT: About 50% of all boys with AS have a paternal family history of autism spectrum disorder. Pre- and perinatal risks appear to be important in about 25% of cases.
OBJECTIVE: Study familial and pre- and perinatal factors in Asperger Syndrome (AS). METHODS: One hundred boys with AS had their records reviewed. "Pathogenetic subgroups" were defined according to presence of medical syndromes/chromosomal abnormalities, indices of familiality, and pre- and perinatal risk factors predisposing to brain damage. RESULTS: No major index of pathogenetic factors was found in 13%, a syndrome/chromosomal abnormality in 8%, pre- or perinatal risk 13%, combined pre- or perinatal risk and family history in 11%, and family history only in 55%. COMMENT: About 50% of all boys with AS have a paternal family history of autism spectrum disorder. Pre- and perinatal risks appear to be important in about 25% of cases.
Authors: Philippe Debeer; H Peeters; S Driess; L De Smet; K Freese; G Matthijs; D Bornholdt; K Devriendt; K-H Grzeschik; J-P Fryns; M Kalff-Suske Journal: Am J Med Genet A Date: 2003-07-01 Impact factor: 2.802
Authors: Katja M Lampi; Liisa Lehtonen; Phuong Lien Tran; Auli Suominen; Venla Lehti; P Nina Banerjee; Mika Gissler; Alan S Brown; Andre Sourander Journal: J Pediatr Date: 2012-06-05 Impact factor: 4.406
Authors: K B Walhovd; L T Westlye; V Moe; K Slinning; P Due-Tønnessen; A Bjørnerud; A van der Kouwe; A M Dale; A M Fjell Journal: AJNR Am J Neuroradiol Date: 2010-03-04 Impact factor: 3.825
Authors: Katja M Lampi; Susanna Hinkka-Yli-Salomäki; Venla Lehti; Hans Helenius; Mika Gissler; Alan S Brown; Andre Sourander Journal: J Autism Dev Disord Date: 2013-11
Authors: K B Walhovd; V Moe; K Slinning; P Due-Tønnessen; A Bjørnerud; A M Dale; A van der Kouwe; B T Quinn; B Kosofsky; D Greve; B Fischl Journal: Neuroimage Date: 2007-04-25 Impact factor: 6.556