Tohshin Go1. 1. Department of Infants' Brain and Cognitive Development, Tokyo Women's Medical University, Tokyo, 162-8666, Japan. gogo@abmes.twmu.ac.jp
Abstract
OBJECTS: Since alkaline urine is a risk factor for urolithiasis, the relationship between antiepileptic drugs and urinary pH was retrospectively studied in epilepsy patients treated with antiepileptic drug monotherapy for more than 1 month. METHODS: A total of 913 urinary samples from antiepileptic drug-treated patients were compared with 780 age-matched control samples, and with 112 samples from epilepsy patients who had not been treated with antiepileptic drugs. The antiepileptic drugs administered were carbamazepine, valproate, phenobarbital, zonisamide, sulthiame, and phenytoin. CONCLUSIONS: The proportion of the acid urine in the valproate-treated patients was lower than that in controls. The proportion of the alkaline urine in the valproate-treated patients was higher than that in controls. This effect was independent of age, sex, and the serum valproate concentration. There was no significant difference in urinary pH among the epilepsy patients treated with other antiepileptic drugs, the epilepsy patients who had not been treated with antiepileptic drugs, and the controls.
OBJECTS: Since alkaline urine is a risk factor for urolithiasis, the relationship between antiepileptic drugs and urinary pH was retrospectively studied in epilepsypatients treated with antiepileptic drug monotherapy for more than 1 month. METHODS: A total of 913 urinary samples from antiepileptic drug-treated patients were compared with 780 age-matched control samples, and with 112 samples from epilepsypatients who had not been treated with antiepileptic drugs. The antiepileptic drugs administered were carbamazepine, valproate, phenobarbital, zonisamide, sulthiame, and phenytoin. CONCLUSIONS: The proportion of the acid urine in the valproate-treated patients was lower than that in controls. The proportion of the alkaline urine in the valproate-treated patients was higher than that in controls. This effect was independent of age, sex, and the serum valproate concentration. There was no significant difference in urinary pH among the epilepsypatients treated with other antiepileptic drugs, the epilepsypatients who had not been treated with antiepileptic drugs, and the controls.
Authors: I E Leppik; L J Willmore; R W Homan; G Fromm; K J Oommen; J K Penry; J C Sackellares; D B Smith; R P Lesser; J D Wallace Journal: Epilepsy Res Date: 1993-02 Impact factor: 3.045
Authors: Marie-Christine Reinert; David Pacheu-Grau; Claudia B Catarino; Thomas Klopstock; Andreas Ohlenbusch; Michael Schittkowski; Ekkehard Wilichowski; Peter Rehling; Knut Brockmann Journal: Orphanet J Rare Dis Date: 2021-02-04 Impact factor: 4.123