Aud Høieggen1, Ingrid Os, Sverre E Kjeldsen. 1. Nyremedisinsk avdeling, Medisinsk divisjon, Ullevål universitetsykehus, 0407 Oslo. aud.hoieggen@ ulleval.no
Abstract
BACKGROUND: Hyperuricaemia is associated with reduced renal function and increased cardiovascular risk. It is still disputed, however, whether hyperuricaemia is an independent cardiovascular risk factor or just a marker of increased cardiovascular risk. MATERIAL AND METHODS: A review of the literature based on Medline is presented and data from the LIFE (Losartan Intervention For Endpoint reduction in hypertension) study discussed in relation to the association between uric acid and cardiovascular events. RESULTS: Epidemiological data have shown an independent relationship between serum uric acid and cardiovascular risk, at least in women. In LIFE, uric acid at baseline corresponded positively with cardiovascular risk in women, though not in men. Differences in serum uric acid during the study could statistically explain 29% of the reduction in cardiovascular events in the losartan group compared to atenolol. INTERPRETATION: These findings support the hypothesis that uric acid is an independent cardiovascular risk factor. Further studies are warranted.
BACKGROUND: Hyperuricaemia is associated with reduced renal function and increased cardiovascular risk. It is still disputed, however, whether hyperuricaemia is an independent cardiovascular risk factor or just a marker of increased cardiovascular risk. MATERIAL AND METHODS: A review of the literature based on Medline is presented and data from the LIFE (Losartan Intervention For Endpoint reduction in hypertension) study discussed in relation to the association between uric acid and cardiovascular events. RESULTS: Epidemiological data have shown an independent relationship between serum uric acid and cardiovascular risk, at least in women. In LIFE, uric acid at baseline corresponded positively with cardiovascular risk in women, though not in men. Differences in serum uric acid during the study could statistically explain 29% of the reduction in cardiovascular events in the losartan group compared to atenolol. INTERPRETATION: These findings support the hypothesis that uric acid is an independent cardiovascular risk factor. Further studies are warranted.